Automated Radiographic Measurements of Knee Osteoarthritis

Objective: Herewith, we report the development of Orthopedic Digital Image Analysis (ODIA) software that is developed to obtain quantitative measurements of knee osteoarthritis (OA) radiographs automatically. Manual segmentation and measurement of OA parameters currently hamper large-cohort analyses, and therefore, automated and reproducible...

Correlation-enhanced neural networks as interpretable variational quantum states

Variational methods have proven to be excellent tools to approximate the ground states of complex many-body Hamiltonians. Generic tools such as neural networks are extremely powerful, but their parameters are not necessarily physically motivated. Thus, an efficient parametrization of the wave function can become challenging. In this Letter we...

Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review

Objective: To summarize available evidence on the association between hip shape as quantified by statistical shape modeling (SSM) and the incidence or progression of hip osteoarthritis. Design: We conducted a systematic search of five electronic databases, based on a registered protocol (available: PROSPERO CRD42020145411). Articles...

Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography

Fluorescence molecular tomography (FMT) emerges as a powerful non-invasive imaging tool with the ability to resolve fluorescence signals from sources located deep in living tissues. Yet, the accuracy of FMT reconstruction depends on the deviation of the assumed optical properties from the actual values. In this work, we improved the accuracy...

Taxonomy of Trust-Relevant Failures and Mitigation Strategies

We develop a taxonomy that categorizes HRI failure types and their impact on trust to structure the broad range of knowledge contributions. We further identify research gaps in order to support fellow researchers in the development of trustworthy robots. Studying trust repair in HRI has only recently been given more interest and we propose a...

Predicting the mechanical hip–knee–ankle angle accurately from standard knee radiographs: a cross-validation experiment in 100 patients

Background and purpose — Being able to predict the hip–knee–ankle angle (HKAA) from standard knee radiographs allows studies on malalignment in cohorts lacking full-limb radiography. We aimed to develop an automated image analysis pipeline to measure the femoro-tibial angle (FTA) from standard knee radiographs and test various FTA definitions...

An automated workflow based on hip shape improves personalized risk prediction for hip osteoarthritis in the CHECK study

Objective: To design an automated workflow for hip radiographs focused on joint shape and tests its prognostic value for future hip osteoarthritis. Design: We used baseline and 8-year follow-up data from 1,002 participants of the CHECK-study. The primary outcome was definite radiographic hip osteoarthritis (rHOA) (Kellgren–Lawrence grade ≥2...

A CMOS SPAD Imager with Collision Detection and 128 Dynamically Reallocating TDCs for Single-Photon Counting and 3D Time-of-Flight Imaging

Per-pixel time-to-digital converter (TDC) architectures have been exploited by single-photon avalanche diode (SPAD) sensors to achieve high photon throughput, but at the expense of fill factor, pixel pitch and readout efficiency. In contrast, TDC sharing architecture usually features high fill factor at small pixel pitch and energy efficient...

Towards monitoring the englacial fracture state using virtual-reflector seismology

In seismology, coda wave interferometry (CWI) is an effective tool to monitor time-lapse changes using later arriving, multiply scattered coda waves. Typically, CWI relies on an estimate of the medium's impulse response. The latter is retrieved through simple time-averaging of receiver-receiver cross-correlations of the ambient field, that is...

Comparing population and incident data for optimal air ambulance base locations in Norway

Background: Helicopter emergency medical services are important in many health care systems. Norway has a nationwide physician manned air ambulance service servicing a country with large geographical variations in population density and incident frequencies. The aim of the study was to compare optimal air ambulance base locations using both...

Exploring optimal air ambulance base locations in Norway using advanced mathematical modelling

Background Helicopter emergency medical services are an important part of many healthcare systems. Norway has a nationwide physician staffed air ambulance service with 12 bases servicing a country with large geographical variations in population density. The aim of the study was to estimate optimal air ambulance base locations. Methods We used...

Dynamic analysis of a diffusing particle in a trapping potential

The dynamics of a diffusing particle in a potential field is ubiquitous in physics, and it plays a pivotal role in single-molecule studies. We present a formalism for analyzing the dynamics of diffusing particles in harmonic potentials at low Reynolds numbers using the time evolution of the particle probability distribution function. We...

HU Protein Induces Incoherent DNA Persistence Length

HU is a highly conserved protein that is believed to play an important role in the architecture and dynamic compaction of bacterial DNA. Its ability to control DNA bending is crucial for functions such as transcription and replication. The effects of HU on the DNA structure have been studied so far mainly by single molecule methods that require...

Force-free measurements of the conformations of DNA molecules tethered to a wall

Using an optimized combination of tethered particle motion method, total internal reflection, and a gold nanobead, we measured the three-dimensional distribution of the free end of a tethered DNA molecule. The distribution along the axial z direction (perpendicular to the surface) is found to be Rayleigh-like, in agreement with wormlike chain...

Energy-based aeroelastic analysis of a morphing wing

Aircraft are often confronted with distinct circumstances during different parts of their mission. Ideally the aircraft should fly optimally in terms of aerodynamic performance and other criteria in each one of these mission requirements. This requires in principle as many different aircraft configurations as there are flight conditions, so...

Design of a recurve actuator for maximum energy efficiency

De veiligheid van boomkorkotters. Deel: Algemeen

De veiligheid van boomkorkotters. Scheepsbewegingen en weerstand