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Effect of benzoic acid on metabolic fluxes in yeasts: A continuous-culture study on the regulation of respiration and alcoholic fermentation

Verduyn, C. (author), Postma, E. (author), Scheffers, W.A. (author), Van Dijken, J.P. (author)

journal article 1992

document

Production of coated detergent enzyme granules

Almeida-Rivera, C.P. (author), Du, P. (author), padios, R.G. (author), Pitchumani, R. (author), Taboada, J.B. (author)

Document(en) uit de collectie Chemische Procestechnologie

report 1999

document

Design of an integrated fermentation-crystallization process applied to the production of DOIP

Blokker, S. (author), Dabkowski, M. (author), Groendijk, W. (author), Renckens, D. (author), De Rond, J. (author)

The design problem of CPD3312 was the comparison of the conventional batch (Base case) and the new integrated fermentation-crystallization process (In Situ Product Removal or ISPR case) in particular for the production of 2 tonnes 6R-dihydrooxoisophorone (DOIP) from 4-oxo-isophorone (OIP) per year. Creativity tools were used to generate...

report 2004

document

Engineering of Saccharomyces cerevisiae for the production of fuel ethanol from xylose

Kuijper, S.M. (author)

For various reasons mankind is looking for alternatives for fossil fuels. One of these alternatives is ethanol made from plant biomass. However, the plant material when broken down by hydrolysis into its sugar monomers contains a significant amount of xylose, a 5-carbon-sugar or pentose. Contrary to the sugars with 6 carbon atoms (hexoses) wild...

doctoral thesis 2006

document

A dynamic and steady state metabolome study of central metabolism and its relation with the penicillin biosynthesis pathway in Penicillium chrysogenum

Nasution, U.D.M. (author)

Abstract not available

doctoral thesis 2007

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Physiological impact and context dependency of transcriptional responses: A chemostat study in Saccharomyces cerevisiae

Tai, S.L. (author)

This thesis is a compilation of a four-year PhD project on bakers' yeast (Saccharomyces cerevisiae). Since the entire S. cerevisiae genome sequence became available in 1996, DNA-microarray analysis has become a popular high-information-density tool for analyzing gene expression in this important industrial microorganism and model eukaryote. This...

doctoral thesis 2007

document

Fumaric acid production by fermentation

Roa Engel, C.A. (author), Straathof, A.J.J. (author), Zijlmans, T.W. (author), Van Gulik, W.M. (author), Van der Wielen, L.A.M. (author)

Abstract The potential of fumaric acid as a raw material in the polymer industry and the increment of cost of petroleum-based fumaric acid raises interest in fermentation processes for production of this compound from renewable resources. Although the chemical process yields 112% w/w fumaric acid from maleic anhydride and the fermentation...

journal article 2008

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Directing product formation by mixed culture fermentation

Temudo, M.F. (author)

Our society is dealing with the shortage of fossil fuels and chemical feedstocks and, on the other hand, with the increase of wastes generated by municipalities, agriculture and industries. Biobased industry, the conversion of renewable resources or wastes to chemicals and fuels, by microbial fermentations or enzymes has been receiving...

doctoral thesis 2008

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Diversity of microbial communities in open mixed culture fermentations: Impact of the pH and carbon source

Temudo, M.F. (author), Muyzer, G. (author), Kleerebezem, R. (author), Van Loosdrecht, M.C.M. (author)

Anaerobic fermentation by an open mixed culture was investigated at different pH values (4–8.5) and with three substrates (glucose, glycerol and xylose). The populations established in each condition were assessed by denaturing gradient gel electrophoresis analysis of the 16S ribosomal RNA gene fragments. The fermentation pattern and the...

journal article 2008

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Xylose anaerobic conversion by open-mixed cultures

Temudo, M.F. (author), Mato, T. (author), Kleerebezem, R. (author), Van Loosdrecht, M.C.M. (author)

Xylose is, after glucose, the dominant sugar in agricultural wastes. In anaerobic environments, carbohydrates are converted into volatile fatty acids and alcohols. These can be used as building blocks in biotechnological or chemical processes, e.g., to produce bioplastics. In this study, xylose fermentation by mixed microbial cultures was...

journal article 2008

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Towards the integration of fermentation and crystallisation - A study on the production of L-phenylalanine

Cuellar Soares, M.C. (author)

Industrial biotechnology can be defined as the utilization of living organisms or their enzymes for the industrial production of food, beverages, commodity chemicals and pharmaceuticals, among others. A biotechnological production process, so-called bioprocess, mostly comprises product formation (e.g. by fermentation) and product recovery and...

doctoral thesis 2008

document

In-situ product recovery from fermentation broths

Van den Berg, C. (author)

Life sciences will be one of the decisive factors in the 21st century. A major part of this field is the so-called white biotechnology, also known as industrial biotechnology. White biotechnology is an emerging field where bio-chemicals are produced using micro-organisms. However, the production of bio-chemicals is severely inhibited due to...

doctoral thesis 2010

document

Structured morphological modeling as a framework for rational strain design of Streptomyces species

Celler, K. (author), Picioreanu, C. (author), Van Loosdrecht, M.C.M. (author), Van Wezel, G.P. (author)

Successful application of a computational model for rational design of industrial Streptomyces exploitation requires a better understanding of the relationship between morphology—dictated by microbial growth, branching, fragmentation and adhesion—and product formation. Here we review the state-of-the-art in modeling of growth and product...

journal article 2012

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Transformation of biomass into commodity chemicals using enzymes or cells

Straathof, A.J.J. (author)

journal article 2013

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Computational fluid dynamics of gassed-stirred fermenters

Gunyol, O. (author)

The current understanding of the transport phenomena involved in the operation of industrial fermenters is not sufficient. This is reflected by the limitations seen in their design and operation. A better insight in the local processes taking place (hydrodynamics, gas dispersion, mixing, microbial kinetics) is required to be able to make a step...

doctoral thesis 2017

document

Integration of Gas Enhanced Oil Recovery in Multiphase Fermentations for the Microbial Production of Fuels and Chemicals

Pedraza de la Cuesta, S. (author), Keijzers, L. (author), van der Wielen, L.A.M. (author), Cuellar Soares, M.C. (author)

In multiphase fermentations where the product forms a second liquid phase or where solvents are added for product extraction, turbulent conditions disperse the oil phase as droplets. Surface-active components (SACs) present in the fermentation broth can stabilize the product droplets thus forming an emulsion. Breaking this emulsion increases...

journal article 2018

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Laboratory evolution for forced glucose-xylose co-consumption enables identification of mutations that improve mixed-sugar fermentation by xylose-fermenting Saccharomyces cerevisiae

Papapetridis, I. (author), Verhoeven, M.D. (author), Wiersma, S.J. (author), Goudriaan, M. (author), van Maris, A.J.A. (author), Pronk, J.T. (author)

Simultaneous fermentation of glucose and xylose can contribute to improved productivity and robustness of yeast-based processes for bioethanol production from lignocellulosic hydrolysates. This study explores a novel laboratory evolution strategy for identifying mutations that contribute to simultaneous utilisation of these sugars in batch...

journal article 2018

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Origin of Lactose Fermentation in Kluyveromyces lactis by Interspecies Transfer of a Neo-functionalized Gene Cluster during Domestication

Varela, Javier A. (author), Puricelli, Martina (author), Ortiz Merino, R.A. (author), Giacomobono, Romina (author), Braun-Galleani, Stephanie (author), Wolfe, Kenneth H. (author), Morrissey, John P. (author)

Humans have used yeasts to make cheese and kefir for millennia, but the ability to ferment the milk sugar lactose is found in only a few yeast species, of which the foremost is Kluyveromyces lactis [1]. Two genes, LAC12 (lactose permease) and LAC4 (lactase), are sufficient for lactose uptake and hydrolysis to glucose and galactose [2]. Here,...

journal article 2019

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Techno-economic assessment of the use of solvents in the scale-up of microbial sesquiterpene production for fuels and fine chemicals

Pedraza de la Cuesta, S. (author), Knopper, L. (author), van der Wielen, L.A.M. (author), Cuellar Soares, M.C. (author)

Sesquiterpenes are a group of versatile, 15-carbon molecules with applications ranging from fuels to fine chemicals and pharmaceuticals. When produced by microbial fermentation at laboratory scale, solvents are often employed for reducing product evaporation and enhancing recovery. However, it is not clear whether this approach constitutes a...

journal article 2019

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Vitamin requirements and biosynthesis in Saccharomyces cerevisiae

Perli, T. (author), Wronska, A.K. (author), Ortiz Merino, R.A. (author), Pronk, J.T. (author), Daran, J.G. (author)

Chemically defined media for yeast cultivation (CDMY) were developed to support fast growth, experimental reproducibility, and quantitative analysis of growth rates and biomass yields. In addition to mineral salts and a carbon substrate, popular CDMYs contain seven to nine B-group vitamins, which are either enzyme cofactors or precursors for...

journal article 2020