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Chorus, C.G. (author), Dekker, T. (author)
This paper introduces to the field of marketing a regret-based discrete choice model for the analysis of multi-attribute consumer choices from multinomial choice sets. This random regret minimization model (RRM), which has two years ago been introduced in the field of transport, forms a regret-based counterpart of the canonical random utility...
conference paper 2013
document
Van Loenhout, M.T. (author), De Vlaminck, I. (author), Flebus, B. (author), Den Blanken, J.F. (author), Zweifel, L.P. (author), Hooning, K.M. (author), Kerssemakers, J.W. (author), Dekker, C. (author)
The functional state of the genome is determined by its interactions with proteins that bind, modify, and move along the DNA. To determine the positions and binding strength of proteins localized on DNA we have developed a combined magnetic and optical tweezers apparatus that allows for both sensitive and label-free detection. A DNA loop, that...
journal article 2013
document
Genani, G. (author), Dekker, M.C. (author), Molenbroek, J.F.M. (author)
An investigation of existing literature reveals that guitar players are most prone to musculoskeletal injuries amongst all musicians. In the light of recent injuries to prominent guitar players such as Eddie Van Halen, this article explores ergonomics of electric guitars. By means of surveys, user observations, biomechanical analysis and...
journal article 2013
document
Lee, M. (author), Lipfert, J. (author), Sanchez, H. (author), Wyman, C. (author), Dekker, N.H. (author)
Human RAD51 is a key protein in the repair of DNA by homologous recombination. Its assembly onto DNA, which induces changes in DNA structure, results in the formation of a nucleoprotein filament that forms the basis of strand exchange. Here, we determine the structural and mechanical properties of RAD51-dsDNA filaments. Our measurements use two...
journal article 2013
document
Dekker, Rianne (author), Belabas, Warda (author), Scholten, Peter (author)
It is often asserted that ethnic minorities have a marginalized position in the city. Interethnic contact theory argues that due to spatial segregation, minorities’ access to interethnic contact is limited and they have less access to social resources. Social media have the potential to overcome spatial boundaries and provide new opportunities...
conference paper 2013
document
Dekker, R. (author)
“A what on a chip?” is what most people ask with disbelief when they hear for the first time of the new and very exciting research area “Organ on a Chip.” The topic has nothing to do with Science Fiction, but everything with a very surprising encounter between two completely different research fields: Microfabrication and Stem-Cell Biology! The...
journal article 2013
document
Moolman, M.C. (author), Huang, Z. (author), Krishnan, S.T. (author), Kerssemakers, J.W.J. (author), Dekker, N.H. (author)
Background: Controlled restriction of cellular movement using microfluidics allows one to study individual cells to gain insight into aspects of their physiology and behaviour. For example, the use of micron-sized growth channels that confine individual Escherichia coli has yielded novel insights into cell growth and death. To extend this...
journal article 2013
document
De Vlaminck, I. (author), Plesa, C. (author), Dekker, C. (author)
patent 2013
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Mimoun, B.A.Z. (author), Pham, H.T.M. (author), Henneken, V. (author), Dekker, R. (author)
The authors have found that patterning polyimide coatings containing organosilane adhesion promoter using pure oxygen plasma resulted in a thin silicon-rich residue layer. They show in this paper that adding small amounts of fluorine-containing gas to the etching gas mixture is necessary in order to achieve residue-free polyimide plasma etching....
journal article 2013
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Dulin, D. (author), Lipfert, J. (author), Moolman, M.C. (author), Dekker, N.H. (author)
To understand genomic processes such as transcription, translation or splicing, we need to be able to study their spatial and temporal organization at the molecular level. Single-molecule approaches provide this opportunity, allowing researchers to monitor molecular conformations, interactions or diffusion quantitatively and in real time in...
journal article 2013
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Vlijm, R. (author), Smitshuijzen, J.S.J. (author), Lusser, A. (author), Dekker, C. (author)
While many proteins are involved in the assembly and (re)positioning of nucleosomes, the dynamics of protein-assisted nucleosome formation are not well understood. We study NAP1 (nucleosome assembly protein 1) assisted nucleosome formation at the single-molecule level using magnetic tweezers. This method allows to apply a well-defined stretching...
journal article 2012
document
Khoshfetrat Pakazad, S. (author), Savov, A. (author), Braam, S.R. (author), Dekker, R. (author)
A platform for the batch fabrication of pneumatically actuated Stretchable Micro-Electrode Arrays (SMEAs) by using state-of-the-art micro-fabrication techniques and materials is demonstrated. The proposed fabrication process avoids the problems normally associated with processing of thin film structures on polydimethylsiloxane (PDMS), by first...
journal article 2012
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Calado, V.E. (author), Schneider, G.F. (author), Theulings, A.M.M.G. (author), Dekker, C. (author), Vandersypen, L.M.K. (author)
We study the formation of wrinkles in graphene upon wet transfer onto a hydrophilic target substrate, whereby draining of water appears to play an important role. We are able to control the orientation of the wrinkles by tuning the surface morphology. Wrinkles are absent in flakes transferred to strongly hydrophobic substrates, a further...
journal article 2012
document
De Vlaminck, I. (author), Henighan, T. (author), Van Loenhout, M.T.J. (author), Burnham, D.R. (author), Dekker, C. (author)
Magnetic tweezers (MT) are a powerful tool for the study of DNA-enzyme interactions. Both the magnet-based manipulation and the camera-based detection used in MT are well suited for multiplexed measurements. Here, we systematically address challenges related to scaling of multiplexed magnetic tweezers (MMT) towards high levels of parallelization...
journal article 2012
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Walstra, D.J.R. (author), De Vroeg, J.H. (author), Van Thiel de Vries, J.S.M. (author), Swinkels, C. (author), Luijendijk, A.P. (author), De Boer, W.P. (author), Hoekstra, R. (author), Hoonhout, B. (author), Henrotte, J. (author), Smolders, T. (author), Dekker, F. (author), Godsey, E. (author)
In order to conceive any realistic plan for post-Katrina island restoration, it is necessary to understand the physical processes that move sand along the littoral drift zone off the coast of Mississippi. This littoral zone influences the character of the Mississippi barrier islands as they exist in an ever changing cycle. To help in this...
conference paper 2012
document
De Vlaminck, I. (author), Van Loenhout, M.T.J. (author), Zweifel, L. (author), Den Blanken, J. (author), Hooning, K. (author), Hage, S. (author), Kerssemakers, J. (author), Dekker, C. (author)
In E. coli homologous recombination, a filament of RecA protein formed on DNA searches and pairs a homologous sequence within a second DNA molecule with remarkable speed and fidelity. Here, we directly probe the strength of the two-molecule interactions involved in homology search and recognition using dual-molecule manipulation, combining...
journal article 2012
document
Van Loenhout, M.T.J. (author), Kerssemakers, J.W.J. (author), De Vlaminck, I. (author), Dekker, C. (author)
We present a three-dimensional tracking routine for nondiffraction-limited particles, which significantly reduces pixel bias. Our technique allows for increased resolution compared to that of previous methods, especially at low magnification or at high signal/noise ratio. This enables tracking with nanometer accuracy in a wide field of view and...
journal article 2012
document
Männik, J. (author), Wu, F. (author), Hol, F.J.H. (author), Bisicchia, P. (author), Sherratt, D.J. (author), Keymer, J.E. (author), Dekker, C. (author)
Cell division in typical rod-shaped bacteria such as Escherichia coli shows a remarkable plasticity in being able to adapt to a variety of irregular cell shapes. Here, we investigate the roles of the Min system and the nucleoid-occlusion factor SlmA in supporting this adaptation. We study “squeezed” E. coli in narrow nanofabricated channels...
journal article 2012
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Pedaci, F. (author), Huang, Z. (author), Van Oene, M. (author), Dekker, N.H. (author)
The optical torque wrench is a laser trapping technique that expands the capability of standard optical tweezers to torque manipulation and measurement, using the laser linear polarization to orient tailored microscopic birefringent particles. The ability to measure torque of the order of kBT (?4 pN nm) is especially important in the study of...
journal article 2012
document
Dekker, N.H. (author), Pedaci, F. (author), Barland, S. (author)
The invention provides a method for sensing with a sensor system an analyte in an analyte fluid. The sensor system comprises a micron scale birefringent entity, a laser unit configured to generate polarized laser light, a polarization rotation device, wherein the laser unit and polarization rotation device are configured to rotate at a...
patent 2012
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