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A principled approach to cross-sector genomic data access

Smith, Marcus (author), Miller, S.R.M. (author)

Genomic data is growing in importance as scientific knowledge and technology develop, and in availability, as direct-to-consumer genomic health testing and recreational genealogy services become more widely utilized. Access to genomic data needs to be considered in light of individual privacy. Cross-sector use of genomic health and ancestry data...

journal article 2021

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Thermodynamic modelling assessment of the ternary system Cs-Mo-O

Smith, A.L. (author), Pham Thi, T. N. (author), Guéneau, C. (author), Dumas, J. (author), Epifano, E. (author), van Burik, W. (author), Dupin, N. (author)

This work reports the thermodynamic modelling assessment of the rather complex Cs-Mo-O system, which is key for the understanding of fission products chemistry in oxide fuelled Light Water Reactors (LWRs) and next generation Sodium-cooled and Lead-cooled Fast Reactors (SFRs and LFRs). The model accounts for the existence of the ternary...

journal article 2021

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Geomorphological mapping in urban areas

Brandolini, Pierluigi (author), Del Monte, Maurizio (author), Faccini, Francesco (author), Cattoor, B. (author), Zwoliński, Zbigniew (author), Smith, Mike (author)

contribution to periodical 2021

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Introducing special issue on photocatalysis and photoelectrochemistry

Batista, Victor (author), Li, Can (author), Smith, W.A. (author), Wang, Dunwei (author)

contribution to periodical 2021

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Risk blindness in local perspectives about the Alberta oil sands hinders Canada's decarbonization

Virla, Luis D. (author), van de Ven, Dirk Jan (author), Sampedro, Jon (author), van Vliet, Oscar (author), Smith, Alistair (author), Pollitt, Hector (author), Della Santina, C. (author)

Local perspectives can conflict with national and international climate targets. This study explores three stakeholder (community, provincial, and federal) perspectives on the Alberta oil sands as risks for a sustainability transition in Canada. In an ex-post analysis, we compared outputs from stakeholder consultations and energy-economy...

journal article 2021

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Operando Infrared Spectroscopy Reveals the Dynamic Nature of Semiconductor-Electrolyte Interface in Multinary Metal Oxide Photoelectrodes

Venugopal, A. (author), Kas, Recep (author), Hau, Kayeu (author), Smith, W.A. (author)

Detailed knowledge about the semiconductor/electrolyte interface in photoelectrochemical (PEC) systems has been lacking because of the inherent difficulty of studying such interfaces, especially during operation. Current understandings of these interfaces are mostly from the extrapolation of ex situ data or from modeling approaches. Hence,...

journal article 2021

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Emerging collaborations at the forefront of growth in electrochemical synthesis

Buonsanti, Raffaella (author), Smith, W.A. (author)

journal article 2021

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Experimental and Computational Exploration of the NaF-ThF₄Fuel System: Structure and Thermochemistry

Schreuder, Maarten B.J.W. (author), Ocadiz flores, J.A. (author), Gheribi, Aimen E. (author), Beneš, Ondrej (author), Griveau, Jean Christophe (author), Colineau, Eric (author), Konings, R. (author), Smith, A.L. (author)

The structural, thermochemical, and thermophysical properties of the NaF-ThF4 fuel system were studied with experimental methods and molecular dynamics (MD) simulations. Equilibrium MD (EMD) simulations using the polarizable ion model were performed to calculate the density, molar volume, thermal expansion, mixing enthalpy, heat capacity, and...

journal article 2021

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Coupled structural-thermodynamic modelling of the molten salt system NaCl-UCl₃

van Oudenaren, G. I.L. (author), Ocadiz flores, J.A. (author), Smith, A.L. (author)

Molten chloride salts are ionic liquids in which the anions and cations exhibit network formation. An attractive salt system for use in molten salt reactors is NaCl-UCl₃, an ionic liquid with complex non-ideal thermodynamic behaviour due to the formation of short-range order. The relationship between local structure and...

journal article 2021

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Drift correction in localization microscopy using entropy minimization

Cnossen, J.P. (author), Cui, Tao Ju (author), Joo, C. (author), Smith, C.S. (author)

Localization microscopy offers resolutions down to a single nanometer but currently requires additional dedicated hardware or fiducial markers to reduce resolution loss from the drift of the sample. Drift estimation without fiducial markers is typically implemented using redundant cross correlation (RCC). We show that RCC has sub-optimal...

journal article 2021

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High Indirect Energy Consumption in AEM-Based CO₂Electrolyzers Demonstrates the Potential of Bipolar Membranes

Blommaert, M.A. (author), Subramanian, S.S. (author), Yang, K. (author), Smith, W.A. (author), Vermaas, D.A. (author)

Typically, anion exchange membranes (AEMs) are used in CO2 electrolyzers, but those suffer from unwanted CO2 crossover, implying (indirect) energy consumption for generating an excess of CO2 feed and purification of the KOH anolyte. As an alternative, bipolar membranes (BPMs) have been suggested, which mitigate the reactant loss by...

journal article 2021

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Theoretical minimum uncertainty of single-molecule localizations using a single-photon avalanche diode array

Houwink, Quint (author), Kalisvaart, D. (author), Hung, S. (author), Cnossen, J.P. (author), Fan, D. (author), Mos, Paul (author), Ülkü, Arin Can (author), Bruschini, Claudio (author), Charbon-Iwasaki-Charbon, E. (author), Smith, C.S. (author)

Single-photon avalanche diode (SPAD) arrays can be used for single-molecule localization microscopy (SMLM) because of their high frame rate and lack of readout noise. SPAD arrays have a binary frame output, which means photon arrivals should be described as a binomial process rather than a Poissonian process. Consequentially, the theoretical...

journal article 2021

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Electricity in the Air: Insights From Two Decades of Advanced Control Research and Experimental Flight Testing of Airborne Wind Energy Systems

Vermillion, Chris (author), Cobb, Mitchell (author), Fagiano, Lorenzo (author), Leuthold, Rachel (author), Diehl, Moritz (author), Smith, Roy S. (author), Wood, Tony A. (author), Rapp, S. (author), Schmehl, R. (author)

Airborne wind energy systems convert wind energy into electricity using tethered flying devices, typically flexible kites or aircraft. Replacing the tower and foundation of conventional wind turbines can substantially reduce the material use and, consequently, the cost of energy, while providing access to wind at higher altitudes. Because the...

review 2021

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Examination of the short-range structure of molten salts: ThF₄, UF₄, and related alkali actinide fluoride systems

Ocadiz flores, J.A. (author), Gheribi, A. E. (author), Vlieland, J. (author), de Haas, D.W. (author), Dardenne, K. (author), Rothe, J. (author), Konings, R. (author), Smith, A.L. (author)

The short-range structures of LiF-ThF4, NaF-AnF4, KF-AnF4, and Cs-AnF4 (An = Th, U), were probed using in situ high temperature Extended X-ray Absorption Fine Structure (EXAFS) spectroscopy. Signally, the EXAFS spectra of pure molten ThF4 and UF4 were measured for the first time. The data were interpreted with the aid of Molecular Dynamics ...

journal article 2021

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Operando Topography and Mechanical Property Mapping of CO₂Reduction Gas-Diffusion Electrodes Operating at High Current Densities

Nesbitt, N.T. (author), Smith, W.A. (author)

Electrochemical atomic force microscopy (EC-AFM) enables measurement of electrode topography and mechanical properties during electrochemical reactions. However, for aqueous-based reactions that make gas products, such as CO2 reduction and water splitting into CO/H2, current densities below 1 mA cm-2 have been necessary to prevent formation...

journal article 2021

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Single objective tilted lightsheet for three-dimensional localization microscopy

Hung, S. (author), Cnossen, J.P. (author), Fan, D. (author), Smith, C.S. (author)

Optical sectioning technologies achieve high precision localization by reducing the background photon count. We use tilted light-sheet microscopy to achieve optical sectioning in localization microscopy, enabling thick sample observation and low background photon count images. A deformable mirror was incorporated to generate a tetrapod point...

conference paper 2021

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New insights and coupled modelling of the structural and thermodynamic properties of the LiF-UF4 system

Ocadiz flores, J.A. (author), Gheribi, A. E. (author), Vlieland, J. (author), Dardenne, K. (author), Rothe, J. (author), Konings, R. (author), Smith, A.L. (author)

© 2021 The Authors LiF-UF4 is a key binary system for molten fluoride reactor technology, which has not been scrutinized as thoroughly as the closely related LiF-ThF4 system. The phase diagram equilibria in the system LiF-UF4 are explored in this work with X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The short-range...

journal article 2021

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Accelerating ¹H NMR Detection of Aqueous Ammonia

Kolen, M. (author), Smith, W.A. (author), Mulder, F.M. (author)

Direct electrolytic N2 reduction to ammonia (NH3) is a renewable alternative to the Haber-Bosch process. The activity and selectivity of electrocatalysts are evaluated by measuring the amount of NH3 in the electrolyte. Quantitative 1H nuclear magnetic resonance (qNMR) detection reduces the bench time to analyze samples of NH3 (present in the...

journal article 2021

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The microscopic distribution of hydrophilic polymers in interpenetrating polymer networks (IPNs) of medical grade silicone

Smith, Gregory N. (author), Brok, Erik (author), Schmiele, Martin (author), Mortensen, Kell (author), Bouwman, W.G. (author), Duif, C.P. (author), Hassenkam, Tue (author), Alm, Martin (author), Thomsen, Peter (author), Arleth, Lise (author)

By introducing hydrophilic polymers into silicone medical devices, highly beneficial biomedical properties can be realized. An established solution to introduce hydrophilic polymers is to form an interpenetrating polymer network (IPN) by performing the hydrogel synthesis in the presence of silicone swollen in supercritical carbon dioxide. The...

journal article 2021

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Selective dendritic localization of mRNA in drosophila mushroom body output neurons

Mitchell, Jessica (author), Smith, C.S. (author), Titlow, Josh (author), Otto, Nils (author), van Velde, P.F. (author), Booth, Martin (author), Davis, Ilan (author), Waddell, Scott (author)

Memory-relevant neuronal plasticity is believed to require local translation of new proteins at synapses. Understanding this process requires the visualization of the relevant mRNAs within these neuronal compartments. Here, we used single-molecule fluorescence in situ hybridization to localize mRNAs at subcellular resolution in the adult...

journal article 2021