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Godino, E. (author), Restrepo Sierra, A.M. (author), Danelon, C.J.A. (author)The reconstitution of basic cellular functions in micrometer-sized liposomes has led to a surge of interest in the construction of synthetic cells. Microscopy and flow cytometry are powerful tools for characterizing biological processes in liposomes with fluorescence readouts. However, applying each method separately leads to a compromise...journal article 2023
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Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author), Lorenowicz, Magdalena J. (author)Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their...journal article 2023
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Wu, Huan (author), Luo, Houcai (author), Zhang, Jingping (author), Zheng, Bofeng (author), Lang, Lei (author), Wang, Zeping (author), Zhang, Kouchi (author), Chen, Xianping (author)To investigate the unclamped inductive switch (UIS) characteristics, 1200 V silicon carbide (SiC) planar MOSFETs with four cell topologies of linear, current sharing linear, square, and hexagon are designed and manufactured. The experimental platform was built and tested. The results show that the single pulse avalanche energy density of the...journal article 2023
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van der Sluis, Tetje C. (author), Beyrend, Guillaume (author), van der Gracht, Esmé T.I. (author), Abdelaal, T.R.M. (author), Jochems, Simon P. (author), Belderbos, Robert A. (author), Wesselink, Thomas H. (author), van Duikeren, Suzanne (author), Arens, Ramon (author)Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting...journal article 2023
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Blanch Jover, A. (author), Dekker, C. (author)The Cdv system is the protein machinery that performs cell division and other membrane-deforming processes in a subset of archaea. Evolutionarily, the system is closely related to the eukaryotic ESCRT machinery, with which it shares many structural and functional similarities. Since its first description 15 years ago, the understanding of the...review 2023
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Zhou, Y. (author), Ibrahim, Aya (author), Muttillo, M. (author), Manganiello, P. (author), Ziar, H. (author), Isabella, O. (author)This paper presents the fundamental study on the relationship between LED light sources and the performance of solar cell as receivers in visible light communication (VLC) links. Here, different colors of LEDs are modulated with a sinusoidal signal, and the bandwidth of the VLC system based on various c-Si PV architectures is characterized at...conference paper 2023
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Bhadra, A. (author), Haverkort, J.W. (author)Microfluidic fuel cells, electrolyzers, and redox flow batteries utilize laminar flow channels to provide reactants, remove products and avoid their crossover. These devices often also employ porous flow-through electrodes as they offer a high surface area for the reaction and excellent mass transfer. The geometrical features of these...journal article 2023
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Disela, R.C. (author), Bussy, Olivier Le (author), Geldhof, Geoffroy (author), Pabst, Martin (author), Ottens, M. (author)Mass-spectrometry-based proteomics is increasingly employed to monitor purification processes or to detect critical host cell proteins in the final drug substance. This approach is inherently unbiased and can be used to identify individual host cell proteins without prior knowledge. In process development for the purification of new...journal article 2023
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Chen, N. (author), Tune, Daniel (author), Buchholz, Florian (author), Roescu, Razvan (author), Zeman, M. (author), Isabella, O. (author), Mihailetchi, Valentin D. (author)In this study, the edge passivation effectiveness and long-term stability of Nafion polymer in n-type interdigitated back contact (IBC) solar cells are investigated. For new module technologies such as half-cut, triple-cut, or shingled modules, cutting of the cells introduces unpassivated edges with a high recombination rate and this limits the...journal article 2023
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Yin, Xiaole (author), Chen, Xi (author), Jiang, Xiao Tao (author), Yang, Ying (author), Li, Bing (author), Shum, Marcus Ho Hin (author), Schmitt, H. (author), Cha, Chang Jun (author), van Loosdrecht, Mark C.M. (author)Surveillance of antibiotic resistance genes (ARGs) has been increasingly conducted in environmental sectors to complement the surveys in human and animal sectors under the "One-Health"framework. However, there are substantial challenges in comparing and synthesizing the results of multiple studies that employ different test methods and...journal article 2023
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Jiang, Bojing (author), Tan, Sin Yen (author), Fang, Shiyu (author), Feng, Xiaohan (author), Park, B.P. (author), Fok, Hong Kiu Francis (author), Yang, Zhongguang (author), Wang, Ri (author), Kou, Songzi (author), Wu, Angela Ruohao (author), Sun, Fei (author)Spider silk is recognized for its exceptional mechanical properties and biocompatibility, making it a versatile platform for developing functional materials. In this study, a modular functionalization strategy for recombinant spider silk is presented using SpyTag/SpyCatcher chemistry, a prototype of genetically encoded click chemistry. The...journal article 2023
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Magdanz, Veronika (author), Klingner, Anke (author), Abelmann, L. (author), Khalil, Islam S.M. (author)Cell membrane potential affects the electrostatic self-assembly of magnetizable nanoparticles around the flagellum of sperm cells, leading to the formation of biohybrid microrobots (i.e., IRONSperm) with various bending stiffness. Here we explain the influence of bull sperm cell membrane potential on the formation of two types of IRONSperm...journal article 2023
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Yarali, E. (author), Zadpoor, A.A. (author), Staufer, U. (author), Accardo, A. (author), Mirzaali, Mohammad J. (author)Mechanical and morphological design parameters, such as stiffness or porosity, play important roles in creating orthopedic implants and bone substitutes. However, we have only a limited understanding of how the microarchitecture of porous scaffolds contributes to bone regeneration. Meta-biomaterials are increasingly used to precisely engineer...review 2023
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Novella-Rausell, Claudio (author), Grudniewska, Magda (author), Peters, Dorien J.M. (author), Mahfouz, A.M.E.T.A. (author)The kidney's cellular diversity is on par with its physiological intricacy; yet identifying cell populations and their markers remains challenging. Here, we created a comprehensive atlas of the healthy adult mouse kidney (MKA: Mouse Kidney Atlas) by integrating 140.000 cells and nuclei from 59 publicly available single-cell and single-nuclei...journal article 2023
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Van de Cauter, L. (author), van Buren, L. (author), Koenderink, G.H. (author), Ganzinger, Kristina A. (author)Creating an artificial cell from the bottom up is a long-standing challenge and, while significant progress has been made, the full realization of this goal remains elusive. Arguably, one of the biggest hurdles that researchers are facing now is the assembly of different modules of cell function inside a single container. Giant unilamellar...review 2023
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Fang, P. (author), Li, Xiao (author), Jiang, X. (author), Hopman, J.J. (author), Bai, Yong (author)Predicting the bending behaviours of a submarine power cable (SPC) is always a tough task due to its complex geometry and inner layer contact, not to mention the stick–slip mechanism. A full-scale finite element model is cumbersome during the early design stage and a more efficient model for practical use is required. Therefore, in this paper...journal article 2023
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Kingma, E. (author), Diepeveen, E.T. (author), Iñigo de la Cruz, L.M. (author), Laan, L. (author)The ability of cells to translate different extracellular cues into different intracellular responses is vital for their survival in unpredictable environments. In Saccharomyces cerevisiae, cell polarity is modulated in response to environmental signals which allows cells to adopt varying morphologies in different external conditions. The...journal article 2023
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Polat, S. (author), Kortlever, R. (author), Eral, H.B. (author)Selective ion separation is a fundamental challenge with applications ranging from the manufacturing of pharmaceuticals & industrial salts to water desalination. In particular, the separation of formate, a primary product of electrochemical carbon dioxide reduction, has attracted attention not only to reduce carbon emissions and energy...journal article 2023
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Kapetanović, M. (author), Nunez, Alfredo (author), van Oort, N. (author), Goverde, R.M.P. (author)Hydrogen fuel cell multiple unit vehicles are acquiring a central role in the transition process towards carbon neutral trains operation in non-electrified regional railway networks. In addition to their primary role as a transport mean, these vehicles offer significant potential for applications in innovative concepts such as smart grids....journal article 2023
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van Veldhuizen, B.N. (author), Zera, E. (author), van Biert, L. (author), Modena, S. (author), Visser, K. (author), Aravind, P.V. (author)Solid Oxide Fuel Cell (SOFC) systems have the potential to reduce emissions from seagoing vessels. However, it is unknown whether ship motions influence the system's operation. In this research, a 1.5 kW SOFC module is operated on an inclination platform that emulates ship motions, to evaluate the influence of static and dynamic inclinations...journal article 2023