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Schwab, Andrea (author), Wesdorp, Marinus A. (author), Xu, J. (author), Abinzano, Florencia (author), Loebel, Claudia (author), Levato, Riccardo (author), Eglin, David (author), Narcisi, Roberto (author), Malda, Jos (author), van Osch, G.J.V.M. (author)Background: The use of acellular hydrogels to repair osteochondral defects requires cells to first invade the biomaterial and then to deposit extracellular matrix for tissue regeneration. Due to the diverse physicochemical properties of engineered hydrogels, the specific properties that allow or even improve the behaviour of cells are not yet...journal article 2023
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Wehrens, Martijn (author), Krah, Laurens H.J. (author), Towbin, Benjamin D. (author), Hermsen, Rutger (author), Tans, S.J. (author)The inherent stochasticity of metabolism raises a critical question for understanding homeostasis: are cellular processes regulated in response to internal fluctuations? Here, we show that, in E. coli cells under constant external conditions, catabolic enzyme expression continuously responds to metabolic fluctuations. The underlying...journal article 2023
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Zhao, Y. (author), Datta, Kunal (author), Paggiaro, Giulia (author), Liu, Hanchen (author), Fardousi, Mohua (author), Santbergen, R. (author), Procel Moya, P.A. (author), Han, C. (author), Yang, G. (author), Weeber, A.W. (author), Zeman, M. (author), Mazzarella, L. (author), Isabella, O. (author)Monolithic perovskite/c-Si tandem solar cells have attracted enormous research attention and have achieved efficiencies above 30%. This work describes the development of monolithic tandem solar cells based on silicon heterojunction (SHJ) bottom- and perovskite top-cells and highlights light management techniques assisted by optical simulation...journal article 2023
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Li, L. (author), Lukszo, Z. (author), Schmitz, J.E.J. (author)Hydrogen is becoming increasingly popular as a clean, secure, and affordable energy source for the future. This study develops an approach for designing a PV–battery–electrolyzer–fuel cell energy system that utilizes hydrogen as a long-term storage medium and battery as a short-term storage medium. The system is designed to supply load demand...journal article 2023
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Zhang, Yuxuan (author), Zhai, Xiaoqiang (author), Zhang, Fengyuan (author), Zhang, Zhongbin (author), Hooman, K. (author), Zhang, Hai (author), Wang, Xiaolin (author)Enhancing gas-liquid mass transfer is key to promote gas hydrate formation kinetics. Encapsulation of CO<sub>2</sub> hydrate is expected to dramatically increase gas-liquid contact to enhance mass transfer. However, gas hydrate encapsulation has never been proposed as the technical issues of gas permeation through capsule shells have never...journal article 2023
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Yang, Sora (author), Klughammer, N. (author), Barth, A. (author), Tanenbaum, M. (author), Dekker, C. (author)Single-molecule fluorescence imaging experiments generally require sub-nanomolar protein concentrations to isolate single protein molecules, which makes such experiments challenging in live cells due to high intracellular protein concentrations. Here, we show that single-molecule observations can be achieved in live cells through a drastic...journal article 2023
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Li, Wenhuai (author), Li, Mengran (author), Guo, Y. (author), Hu, Zhiwei (author), Zhou, Chuan (author), Brand, Helen E.A. (author), Peterson, Vanessa K. (author), Pao, Chih Wen (author), Chen, Chien Te (author)Oxygen-ion conducting perovskite oxides are important functional materials for solid oxide fuel cells and oxygen-permeable membranes operating at high temperatures (>500 °C). Co-doped perovskites have recently shown their potential to boost oxygen-related kinetics, but challenges remain in understanding the underlying mechanisms. This...journal article 2023
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Polat, S. (author), Kortlever, R. (author), Eral, H.B. (author)Electrochemical carbon dioxide (CO<sub>2</sub>) reduction is a promising route to convert intermittent renewable energy into fuels and valuable chemical products. Separation of CO<sub>2</sub> reduction products by ion-selective electrochemical technology may play a decisive role in the pursuit of commercially viable CO<sub>2</sub> reduction...journal article 2023
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Liu, H. (author), Nadar, R.A. (author), Fauzia, R.P. (author), Laan, A.C. (author), Wang, R. (author), van Cooten, Quenteijn (author), Carroll, E.C.M. (author), Eelkema, R. (author), Denkova, A.G. (author)Combination of therapies is a common strategy in cancer treatment. Such combined therapies only have merit provided that there is superior therapeutic outcome with fewer side effects, compared to single therapies. Here, this work explores the possibility to combine chemotherapy with radionuclide therapy using polymeric micelles as a delivery...journal article 2023
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Abil, Z. (author), Restrepo Sierra, A.M. (author), Danelon, C.J.A. (author)In cell-free gene expression, low input DNA concentration severely limits the phenotypic output, which may impair in vitro protein evolution efforts. We address this challenge by developing CADGE, a strategy that is based on clonal isothermal amplification of a linear gene-encoding dsDNA template by the minimal Φ29 replication machinery and...journal article 2023
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da Silva, Renan F. (author), Hansen, Jeff E. (author), Lowe, Ryan J. (author), Rijnsdorp, D.P. (author), Buckley, Mark L. (author)Nearshore rocky reefs with scales of order 10–100 m are common along the world's coastline and often shape wave-driven hydrodynamics and shoreline morphology in their lee. The interaction of waves with these reefs generally results in either two or four-cell mean circulation systems (2CC and 4CC, respectively), with diverging flows behind the...journal article 2023
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Ji, Encheng (author), Leijsten, Lieke (author), Witte-Bouma, Janneke (author), Rouchon, Adelin (author), Di Maggio, Nunzia (author), Banfi, Andrea (author), van Osch, G.J.V.M. (author), Farrell, Eric (author), Lolli, Andrea (author)Tissue engineering bone via endochondral ossification requires the generation of a cartilage template which undergoes vascularisation and remodelling. While this is a promising route for bone repair, achieving effective cartilage vascularisation remains a challenge. Here, we investigated how mineralisation of tissue-engineered cartilage...journal article 2023
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Stoter, Stein K.F. (author), Divi, Sai C. (author), van Brummelen, E. Harald (author), Larson, Mats G. (author), de Prenter, Frits (author), Verhoosel, Clemens V. (author)In this article, we study the effect of small-cut elements on the critical time-step size in an immersogeometric explicit dynamics context. We analyze different formulations for second-order (membrane) and fourth-order (shell-type) equations, and derive scaling relations between the critical time-step size and the cut-element size for various...journal article 2023
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Geelhoed, Jeanine S. (author), Thorup, Casper A. (author), Bjerg, Jesper J. (author), Schreiber, Lars (author), Nielsen, Lars Peter (author), Schramm, Andreas (author), Meysman, F.J.R. (author), Marshall, Ian P.G. (author)Bacterial cells can vary greatly in size, from a few hundred nanometers to hundreds of micrometers in diameter. Filamentous cable bacteria also display substantial size differences, with filament diameters ranging from 0.4 to 8 µm. We analyzed the genomes of cable bacterium filaments from 11 coastal environments of which the resulting 23 new...journal article 2023
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Peng, Q. (author), Vermolen, F.J. (author), Weihs, D. (author)Cancer cell migration between different body parts is the driving force behind cancer metastasis, which causes mortality of patients. Migration of cancer cells often proceeds by penetration through narrow cavities in possibly stiff tissues. In our previous work [12], a model for the evolution of cell geometry is developed, and in the current...book chapter 2023
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Kuruganti, V.V. (author), Mazurov, Alexander (author), Seren, Sven (author), Isabella, O. (author), Mihailetchi, Valentin D. (author)In this work, we developed an in situ annealing process to crystallize boron-doped amorphous silicon [a-Si(p+)] layers deposited by atmospheric pressure chemical vapour deposition (APCVD) to form boron-doped polycrystalline silicon [poly-Si(p+)] layers. The influence of the temperature profiles during a-Si(p+) inline deposition on structural,...journal article 2023
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Akolawala, Q. (author), Keuning, F.E. (author), Rovituso, M. (author), van Burik, Wouter (author), van der Wal, E.M. (author), Versteeg, Henri H. (author), Rondon, Araci M.R. (author), Accardo, A. (author)Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. While X-ray radiotherapy and chemotherapy remain the current standard, proton beam therapy is an appealing alternative as protons can damage cancer cells while sparing the surrounding healthy tissue. However, the effects of protons on in vitro GBM models...journal article 2023
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Husseini, Abbas Ali (author), Yazdani, Ali Mohammad (author), Ghadiri, Fatemeh (author), Sisman, A.S. (author)We developed a microchip device using surface acoustic waves (SAW) and sharp-edge glass microparticles to rapidly lyse low-level cell samples. This microchip features a 13-finger pair interdigital transducer (IDT) with a 30-degree focused angle, creating high-intensity acoustic beams converging 6 mm away at a 16 MHz frequency. Cell lysis is...journal article 2023
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Hersyandika, Rizqi (author), Rossanese, Marco (author), Lutu, Andra (author), Yang, Miao (author), Wang, Q. (author), Pollin, Sofie (author)This paper studies a promising use case of a private 5G network for the sports industry: wearable bodycams and sensors in a football match. This use case requires a reliable and dedicated massive MIMO network to provide uniform coverage with a high capacity in the whole pitch area. The coverage of co-located and distributed (cell-free) massive...conference paper 2023
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Henzel, J. (author), Bakker, N.J. (author), Najafi, Mehrdad (author), Zardetto, Valerio (author), Veenstra, Sjoerd (author), Isabella, O. (author), Mazzarella, L. (author), Weeber, A.W. (author), Theelen, Mirjam (author)Nonequal current generation in the cells of a photovoltaic module, e.g., due to partial shading, leads to operation in reverse bias. This quickly causes a significant efficiency loss in perovskite solar cells. We report a more quantitative investigation of the reverse bias degradation. Various small reverse biases (negative voltages) were...journal article 2023