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Meng, Li (author), Zhao, Panpan (author), Jiang, Yucheng (author), You, Jiawen (author), Xu, Zhiyan (author), Yu, K. (author), Boccaccini, Aldo R. (author), Ma, Junqing (author), Zheng, K. (author)Bioactive glass nanoparticles (BGNs) are well-recognized multifunctional biomaterials for bone tissue regeneration due to their capability to stimulate various cellular processes through released biologically active ions. Understanding the correlation between BGN composition and cellular responses is key to developing clinically usable BGN...journal article 2024
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Rahmani, N. R. (author), Belluomo, R. (author), Kruyt, M. C. (author), Gawlitta, D. (author), Joosten, L. A.B. (author), Weinans, Harrie (author), Croes, M. (author)Macrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metabolic shifts occur during specific immune training of macrophages that affect their functional state, resulting in heightened (trained) or reduced (tolerant) responses upon exposure to a second stimulus. This is...journal article 2024
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Jahanmard, F. (author), Khodaei, A. (author), Flapper, Jasper (author), Dogan, O. (author), Roohi, K. (author), Taheri, P. (author), Weinans, Harrie (author), Storm, G. (author), Croes, M. (author), Mastrobattista, E. (author), Amin Yavari, S. (author)Despite being the most widely used biomaterials in orthopedic surgery, metallic implants do not induce new bone growth because they are bioinert. Surface biofunctionalization of implants with immunomodulatory mediators is a recent approach to promote osteogenic factors that facilitate bone regeneration. Liposomes (Lip) can be used as a low-cost,...journal article 2023
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Siverino, Claudia (author), Fahmy-Garcia, Shorouk (author), Niklaus, Viktoria (author), Kops, Nicole (author), Dolcini, Laura (author), Misciagna, Massimiliano Maraglino (author), Ridwan, Yanto (author), Farrell, Eric (author), van Osch, G.J.V.M. (author), Nickel, Joachim (author)Bone Morphogenetic proteins (BMPs) like BMP2 and BMP7 have shown great potential in the treatment of severe bone defects. In recent in vitro studies, BMP9 revealed the highest osteogenic potential compared to other BMPs, possibly due to its unique signaling pathways that differs from other osteogenic BMPs. However, in vivo the bone forming...journal article 2023
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Vledder, Amária (author)Delayed healing or non-union of bone fractures are still clinically and economically relevant problems. Bone healing includes pro- and anti-inflammatory phases, which proved crucial for successful healing. Being able to modulate these inflammatory responses could potentially promote bone fracture healing. Dendritic cells play important roles in...master thesis 2022
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Nouri Goushki, M. (author)Osteoimmunomodulation (OIM) is a mechanism through which orthopedic biomaterials may modulate the function of immune cells to promote osteogenesis. OIM is considered a potentially effective way for improving osseointegration. The surface characteristics of orthopedic implants (e.g., topography, wettability, surface chemistry, and charge) can...doctoral thesis 2022
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Golafshan, Nasim (author), Willemsen, K. (author), Kadumudi, Firoz Babu (author), Vorndran, Elke (author), Dolatshahi-Pirouz, Alireza (author), Weinans, Harrie (author), van der Wal, Bart C.H. (author), Malda, Jos (author), Castilho, Miguel (author)Osteoarthritis of the hip is a painful and debilitating condition commonly occurring in humans and dogs. One of the main causes that leads to hip osteoarthritis is hip dysplasia. Although the current surgical methods to correct dysplasia work satisfactorily in many circumstances, these are associated with serious complications, tissue...journal article 2021
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Salandova, M. (author), van Hengel, I.A.J. (author), Apachitei, I. (author), Zadpoor, A.A. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author)Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper,...review 2021
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Additive manufacturing of non-assembly deployable mechanisms for the treatment of large bony defectsLeeflang, M.A. (author), Bobbert, F.S.L. (author), Zadpoor, A.A. (author)Porous biomaterials are often used to treat large bony defects or fractured vertebras. Most of such biomaterials are made of metals and their alloys and have a pre-defined, fixed shape. Due to their predefined fixed shape, however, they are not suitable for implantation through minimally invasive surgical procedures. To overcome this problem,...journal article 2021
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De Witte, Tinke Marie (author), Wagner, Angela M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas A. (author)To guide the natural bone regeneration process, bone tissue engineering strategies rely on the development of a scaffold architecture that mimics the extracellular matrix and incorporates important extracellular signaling molecules, which promote fracture healing and bone formation pathways. Incorporation of growth factors into particles...journal article 2020
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Koolen, Marianne (author), Amin Yavari, S. (author), Lietaert, Karel (author), Wauthle, Ruben (author), Zadpoor, A.A. (author), Weinans, Harrie (author)Additively manufactured (AM) porous metallic biomaterials, in general, and AM porous titanium, in particular, have recently emerged as promising candidates for bone substitution. The porous design of such materials allows for mimicking the elastic mechanical properties of native bone tissue and showed to be effective in improving bone...journal article 2020
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de Witte, Tinke Marie (author), Wagner, Angela M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas A. (author)Bone tissue engineering strategies have been developed to address the limitations of the current gold standard treatment options for bone-related disorders. These systems consist of an engineered scaffold that mimics the extracellular matrix and provides an architecture to guide the natural bone regeneration process, and incorporated growth...journal article 2020
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Nouri Goushki, M. (author), Sharma, Abhishek (author), Sasso, L. (author), Zhang, Shuang (author), van der Eerden, B.C.J. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Manufacturing high throughput in vitro models resembling the tissue microenvironment is highly demanded for studying bone regeneration. Tissues such as bone have complex multiscale architectures inside which cells reside. To this end, engineering a microfluidic platform incorporated with three-dimensional (3D) microscaffolds and submicron...journal article 2019
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Developing a microfluidic device incorporating submicron topographies for studying bone regenerationSharma, Abhishek (author)A major challenge facing the study of bone regeneration today is the inability to mimic the tissue microenvironment and the factors comprising it. Organ-on-chip based microfluidic systems today aim at doing so by dynamically culturing living cells in them. These are preferred owing to their small feature sizes, laminar flows, high throughput,...master thesis 2018
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De Witte, Tinke (author)In recent years, bone tissue engineering has emerged as a promising strategy to overcome the limitations of current ‘gold standard’ treatment options for bone disorders such as bone autografts and allografts. Bone tissue engineering strategies rely on the development of a scaffold that mimics the extracellular matrix, thereby providing an...master thesis 2018
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Bobbert, F.S.L. (author), Lietaert, K. (author), Eftekhari, A.A. (author), Pouran, B. (author), Ahmadi, S.M. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Porous biomaterials that simultaneously mimic the topological, mechanical, and mass transport properties of bone are in great demand but are rarely found in the literature. In this study, we rationally designed and additively manufactured (AM) porous metallic biomaterials based on four different types of triply periodic minimal surfaces (TPMS)...journal article 2017
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Hedayati, R. (author), Janbaz, S. (author), Sadighi, M. (author), Mohammadi-Aghdam, M. (author), Zadpoor, A.A. (author)Although the initial mechanical properties of additively manufactured porous biomaterials are intensively studied during the last few years, almost no information is available regarding the evolution of the mechanical properties of implant-bone complex as the tissue regeneration progresses. In this paper, we studied the effects of tissue...journal article 2017
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Bobbert, F.S.L. (author)Scaffolds for bone regeneration have been investigated as bone substitutes in critical sized bone defects. It is known that the architecture of these scaffolds is important for the bone regeneration process, which depends on cell response and vascular ingrowth into the scaffold. With advanced fabrication techniques, such as selective laser...master thesis 2016
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Van der Stok, J. (author), Koolen, M.K.E. (author), De Maat, M.P.M. (author), Amin Yavari, S. (author), Alblas, J. (author), Patka, P. (author), Verhaar, J.A.N. (author), Van Lieshout, E.E.M. (author), Zadpoor, A.A. (author), Weinans, H.H. (author), Jahr, H. (author)Regeneration of load-bearing segmental bone defects is a major challenge in trauma and orthopaedic surgery. The ideal bone graft substitute is a biomaterial that provides immediate mechanical stability, while stimulating bone regeneration to completely bridge defects over a short period. Therefore, selective laser melted porous titanium,...journal article 2015