Assessment of Predictive Genomic Biomarkers for Response to Cisplatin-based Neoadjuvant Chemotherapy in Bladder Cancer

Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy is recommended for patients with muscle-invasive bladder cancer (MIBC). It has been shown that somatic deleterious mutations in ERCC2, gain-of-function mutations in ERBB2, and alterations in ATM, RB1, and FANCC are correlated with pathological response to NAC in...

Wind load estimation and virtual sensing in long-span suspension bridges using physics-informed Gaussian process latent force models

Wind loading is an essential aspect in the design and assessment of long-span bridges, but it is often not well-known and cannot be measured directly. Most structural health monitoring systems can easily measure structural responses at discrete locations using accelerometers. This data can be combined with reduced-order modal models in Kalman...

A general substructure-based framework for input-state estimation using limited output measurements

This paper presents a general framework for estimating the state and unknown inputs at the level of a system subdomain using a limited number of output measurements, enabling thus the component-based vibration monitoring or control and providing a novel approach to model updating and hybrid testing applications. Under the premise that the...

Full-field response monitoring in structural systems driven by a set of identified equivalent forces

Kalman-type filters for coupled input-state estimation can be used to estimate the full-field dynamic response of structures from only a limited set of vibration measurements. The use of these coupled estimators allows for response prediction to be performed in the absence of any knowledge of both the dynamic evolution and spatial...

On the use of equivalent forces for structural health monitoring based on joint input-state estimation algorithms

For the monitoring of large structures where the loading is typically characterized by large uncertainties in temporal and/or spatial evolution, algorithms capable of estimating a set of response driving equivalent forces are strongly desired. In this context, several Kalman-type coupled input-state and coupled input-state-parameter filters...