The Lloyd Hotel in Amsterdam played an important role in the early 20th century as a migrant hotel for Eastern Europeans on their journey to South America. The hotel is build by the Koninklijke Hollandsche Lloyd and aligned with needs of the Eastern Port area, which was developing into a major centre for global trade and migration. The hotel offered a fully equipped and controlled environment for Europeans migrating overseas, with among others medical, administrative and sleep accomodation amenities. Using both archival and literature research, this thesis explores how the hotel’s foundation and function relates to the spatial and social development of the Eastern Port Area in the 20th century. A comparison with Antwerp’s Red Star Line complex highlights the unique characteristics of Amsterdam’s centralized model. The Lloyd Hotel mirrors the urban development, the migration flow and the changing port infrastructure in the 20th century.