JC
J. Chu
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Resilient Coastal Landscapes
Landscape architecture design explorations in the Pearl River Delta, Ningshao Plain, Mumbai and Bangkok through five MSc-graduation projects
The Resilient Coastal Landscapes graduation lab explores the potential of a landscape-based regional design approach to contribute to more resilient coastal landscapes around the globe. Such an approach addresses the interaction between the natural and urban landscape throughout the scales of space and time. It takes the landscape as the basis for sustainable urban development and employs research through design as a strategy to explore the possibilities of landscape architecture principles for water sensitive design, nature-based solutions, heritage protection, and socio-ecological inclusive development. This landscape approach is transdisciplinary in nature and exploits the power of design to address the complex challenges of our times while connecting long-term strategies and short-term interventions. The projects presented here showcase the wide range of possibilities of the landscape-approach in nature conservation, reduce flood risks, promote sustainable urban transformation and achieve a symbiosis between nature and culture.
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The Resilient Coastal Landscapes graduation lab explores the potential of a landscape-based regional design approach to contribute to more resilient coastal landscapes around the globe. Such an approach addresses the interaction between the natural and urban landscape throughout the scales of space and time. It takes the landscape as the basis for sustainable urban development and employs research through design as a strategy to explore the possibilities of landscape architecture principles for water sensitive design, nature-based solutions, heritage protection, and socio-ecological inclusive development. This landscape approach is transdisciplinary in nature and exploits the power of design to address the complex challenges of our times while connecting long-term strategies and short-term interventions. The projects presented here showcase the wide range of possibilities of the landscape-approach in nature conservation, reduce flood risks, promote sustainable urban transformation and achieve a symbiosis between nature and culture.
Abstract
(2016)
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Amit Deshmukh, W van Winden, M Reuss, Henk Noorman, Cees Haringa, Rob Mudde, Sef Heijnen, Walter van Gulik, Wenjun Tang, J. Xia, J Chu
The objective of this research study is to be able to scale-up and optimize aerobic fermentation processes via computer simulations. As an example the production of penicillin by P. chrysogenum is studied. In vivo kinetics of the cell can be understood by conducting stimulus response and scale down experiments. These experiments provide dynamic information that can be used to estimate parameters of enzyme kinetic models. The transport phenomena inside the bioreactor can by understood by solving hydrodynamic model using computational fluid dynamics (CFD). Thus, with information from intracellular and extracellular environments, an integrated model is solved using CFD. In these simulations, the multiphase flow and transport phenomena taking place inside the bioreactor are simulated, and integrated with the microbial reaction kinetics. The micro-organisms inside the reactor are followed along their trajectories, where they experience a changing environment. The dynamic response of the cells to this environment dictates the productivity and selectivity of the cells. By simulating both the flow in the reactor and the response of the cells, the entire process inside the bioreactor can be assessed and scaled-up and optimization can be done without the need of costly experiments, both in time and financial resources.
...
The objective of this research study is to be able to scale-up and optimize aerobic fermentation processes via computer simulations. As an example the production of penicillin by P. chrysogenum is studied. In vivo kinetics of the cell can be understood by conducting stimulus response and scale down experiments. These experiments provide dynamic information that can be used to estimate parameters of enzyme kinetic models. The transport phenomena inside the bioreactor can by understood by solving hydrodynamic model using computational fluid dynamics (CFD). Thus, with information from intracellular and extracellular environments, an integrated model is solved using CFD. In these simulations, the multiphase flow and transport phenomena taking place inside the bioreactor are simulated, and integrated with the microbial reaction kinetics. The micro-organisms inside the reactor are followed along their trajectories, where they experience a changing environment. The dynamic response of the cells to this environment dictates the productivity and selectivity of the cells. By simulating both the flow in the reactor and the response of the cells, the entire process inside the bioreactor can be assessed and scaled-up and optimization can be done without the need of costly experiments, both in time and financial resources.