Low-rise masonry buildings worldwide frequently feature unreinforced masonry (URM) walls coupled with various pitched roof configurations supported by masonry gables. Past earthquakes have highlighted the vulnerability of these components to out-of-plane seismic loads due to their high slenderness, insufficient roof connections, and exposure to amplified accelerations while being subjected to minimal overburden due to their location at the upper part of buildings. This study presents key insights from the experimental campaign of the ERIES-SUPREME project, aimed at enhancing the understanding of the out-of-plane seismic behavior of masonry gables. Incremental dynamic tests were performed on three full-scale URM gables, simulating both induced and tectonic earthquake scenarios until collapse, using two shake tables. Differential motions at the top and bottom tables reproduced the interaction of the gables with three different roof diaphragm configurations, each introducing a unique filtering effect on the seismic input. The outcomes of the experiments can be used for refining existing numerical modelling strategies as well as contribute to developing improved tools for the seismic assessment of URM gables.