The 2011 Great East Japan Earthquake had a devastating impact on the town of Otsuchi in Iwate Prefecture, resulting in 1,234 immediate deaths and 59.6% of residential houses being fully damaged amongst other severe consequences. The post-disaster Reconstruction Plan (2011-2018) of this town focused on rebuilding the previously existing town with large-scale engineered interventions, resulting in a fragmented set of spatial interventions which solve problems in a single faceted way. The management of a post-tsunami reconstruction process should represent a resilient design for the future. This paper demonstrates that a modified land use design, developed and achieved through an interdisciplinary approach, represents a holistic solution to the drawbacks of the reconstruction plan. Through an iterative framework, site-specific strategies are developed at the urban and the building scale that combine safety and livability by finding synergies among disciplinary fields in an integrated manner. The result of this paper is a quantified evaluation of the reduction in flood risk achieved with a new design, making spatially evident the areas in which a refinement is required to mitigate flood damage. Subject: tsunami; interdisciplinary; resilience; spatial planning; strategy