While conventionally manufactured metallic biomaterials can hardly meet all the requirements for bone implants including complex geometry, exact dimensions, adequate biodegradability, bone-matching mechanical properties, and biological function, two additional tools have recently appeared in the arsenal of biomaterials scientists which promise to deliver the desired combination of properties. First, the unique mechanical, electrical, and biological properties of graphene (Gr) and its derivatives (GDs), e.g., a Young's modulus up to 1 TPa, can be utilized to create metal matrix composites in which GDs of varied contents (typically not more than 2 wt%), sizes (lateral sizes from a few nanometers to several micrometers), surface areas (up to the theoretical value of 2630 m²/g), and layer numbers (typically up to 10) are embedded in the biodegradable metal matrix, thereby endowing the composite implants with extraordinary properties. Second, the distinct advantages of additive manufacturing (AM) make it possible for GD-containing composite materials to precisely mimic the complex shapes and structures of bones at multiple length scales. Here, a comprehensive review of the recent advances in the development of GD-containing biodegradable metal matrix composites (GBMMCs), ranging from composite fabrication, including composite powder preparation, and AM processes, to the evaluation of AM composites in terms of their mechanical and biological properties, is presented. Furthermore, the constraints in processing composite powders, the advantages and disadvantages of applicable AM techniques, and the mechanisms of mechanical reinforcement, biodegradation modulation, osteogenesis improvement, and cytotoxicity/antibacterial balance are critically analyzed. Thereafter, the foreseeable challenges faced in the development of the next-generation of bone implants based on GBMMCs are presented and some future directions of research are identified.

Zinc (Zn) has emerged as a promising biodegradable metal for bone tissue engineering, yet fabricating porous scaffolds via laser-based additive manufacturing (AM) remains challenging due to Zn evaporation. This study presents the successful fabrication of porous Zn scaffolds via extrusion-based AM through systematic ink formulation and sintering optimization. Printability was optimized through rheological analysis of 50–56 vol % Zn-loaded inks, while sintering conditions were refined within a precise temperature window. SEM and micro-CT characterized sintering quality and quantified pore defects. Optimal scaffolds, printed with 53 vol % ink and sintered at 415 °C for 5 h, achieved 40 ± 3% absolute porosity with minimal evaporation, attributed to a hybrid solid-liquid phase sintering mechanism. The scaffolds exhibited trabecular bone-matching mechanical properties with compressive yield strength of 16.1 ± 1.3 MPa and elastic modulus of 1.4 ± 0.1 GPa. In vitro biodegradation in r-SBF showed a corrosion rate of 0.03 ± 0.01 mm/year after 28 days, with biodegradation products including ZnO, Ca₃(PO₄)₂, and Zn-phosphate/chloride hydrates. Electrochemical tests demonstrated increasing polarization resistance (21.1 ± 3.8 kΩ·cm²) and passivation behavior. Indirect cytocompatibility assays showed > 90% metabolic activity for MC3T3-E1 cells in ≤ 50% Zn extracts, while direct seeding confirmed cell adhesion. These results establish extrusion-based AM as a viable route for fabricating Zn scaffolds with tailored porosity, controlled biodegradation, bone-like properties, and acceptable cytocompatibility, advancing the development of Zn-based biodegradable implants. Statement of significance Although laser-based additive manufacturing of pure zinc and its alloys is becoming increasingly mature, its inherent drawbacks, such as evaporation-driven composition loss and melt-pool instabilities, remain non-negligible and underscore the need to develop and apply alternative AM strategies for Zn-based bone scaffolds. We presented an extrusion-based route to fabricate porous Zn bone scaffolds and establish an end-to-end workflow spanning ink formulation, debinding, sintering, and multi-scale characterization. By tailoring the binder system and defining a robust thermal window, we achieved high-fidelity architectures with densified struts. The resulting scaffolds displayed bone-mimicking mechanical behavior together with predictable in-vitro degradation and cytocompatibility. Our work positions extrusion-based 3D printing as a practical manufacturing platform for Zn-based biodegradable bone substitutes.

Oxide dispersion strengthened(ODS) steels and W play an important role in plasma facing components(PFCs).However, complex multi-material structures in PFCs are manufactured by assembling discrete components using conventional techniques and subsequently fused together by a welding process, which creates weak interface zones with limited performance. In this study, a W/ODS-316L multi-material structures were integrally fabricated utilizing the laser powder bed fusion (LPBF) methodology. The study delves into the examination of interfacial diffusion characteristics, the underlying interfacial bonding mechanism, and the mechanical properties of the fabricated structures. The results showed that a good metallurgical bond in W/ODS-316L multi-material interfaces was attributed to Marangoni convection and the development of a keyhole during the forming process. These phenomena induced intensive elemental diffusion across the interface, resulting in a robust metallurgical bond. Furthermore, the presence of Y elements in the molten pool led to their attachment to the surface of un-melted W powder due to Marangoni convection. It caused abnormal diffusion of Y elements towards the pure W side of the interface. The Y element reduced the proportion of large-angle grain boundaries (LAGBs) of W close to the interface, from 36.44% to 18.90%, which further inhibited the initiation and extension of cracks. And the interfacial bonding strength reached 130.42 ± 3.27 MPa. Finally, the effect of W/steel composition gradient on the bonding phenomenon could provide a reference for the composition design and regulation of the bonding effect at multi-material interfaces. The utilization of LPBF technology for fabricating W/ODS-316L multi-material structures presents an alternative viable approach for PFC preparation.

Porous NiTi lattice structures are widely used in the manufacture of crucial components owing to their excellent shape memory effect, superelasticity, and high damping capacities. However, the specific strength and lightweight characteristics of porous NiTi lattice structures fabricated by conventional technologies are limited by unpredictability. In this work, three types of porous NiTi structures based on triply periodic minimal surface (TPMS) – Diamond, Gyroid, and Primitive – were designed and manufactured by the laser powder bed fusion (LPBF) additive manufacturing process. This work demonstrates LPBF is a feasible and efficient approach to fabricate highly accurate porous NiTi TPMS structures. Moreover, the influence of each of these structures on the mechanical and shape memory properties was investigated. Among the three structures, Gyroid had the smallest volume fraction deviation. Furthermore, the Diamond structure had the largest compressive modulus (782.82 MPa) and ultimate yield strength (163.14 MPa). The Gyroid and Primitive structures exhibit excellent elastic recovery deriving from high values of compressive modulus (662.44 MPa, and 703.29 MPa), and can maintain reliable structural robustness. The Primitive structure exhibited the lowest mechanical properties (37.80 MPa). During the cyclic compression test, Gyroid and Primitive show a smaller unrecovered strain than Diamond. Primitive shows the largest recovered strain during the heating process (6.98%). The higher mechanical flexibility of Primitive structure endows this structure with higher recovery ratio. During the direct compression test, the residual strain exhibits a positive correlation with the loading strain. All three structures exhibit good deformation recovery capability with a strain of 4%. At a strain of 12%, recovered strain during heating became the dominant factor in the recovery of the TPMS structure. Overall, porous NiTi TPMS structures are capable of reversible compressibility composed of rapid elastic recovery and controllable shape memory recovery. The unique performance of porous NiTi TPMS structure fabricated by LPBF renders it a highly efficiency energy-absorbing structure.