MK
Authored
16 records found
Redesigning food protein formulations with empirical phase diagrams
A case study on glycerol-poor and glycerol-free formulations
Redesigning existing food protein formulations is necessary in situations where food authorities propose dose adjustments or removal of currently employed additives. Redesigning formulations involves evaluating substitute additives to obtain similar long-term physical stability a
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High-throughput computational pipeline for 3-D structure preparation and in silico protein surface property screening
A case study on HBcAg dimer structures
Knowledge-based experimental design can aid biopharmaceutical high-throughput screening (HTS) experiments needed to identify critical manufacturability parameters. Prior knowledge can be obtained via computational methods such as protein property extraction from 3-D protein struc
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High-throughput computational pipeline for 3-D structure preparation and in silico protein surface property screening
A case study on HBcAg dimer structures
Knowledge-based experimental design can aid biopharmaceutical high-throughput screening (HTS) experiments needed to identify critical manufacturability parameters. Prior knowledge can be obtained via computational methods such as protein property extraction from 3-D protein struc
...
High-throughput computational pipeline for 3-D structure preparation and in silico protein surface property screening
A case study on HBcAg dimer structures
Knowledge-based experimental design can aid biopharmaceutical high-throughput screening (HTS) experiments needed to identify critical manufacturability parameters. Prior knowledge can be obtained via computational methods such as protein property extraction from 3-D protein struc
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The transition to continuous biomanufacturing is considered the next step to reduce costs and improve process robustness in the biopharmaceutical industry, while also improving productivity and product quality. The platform production process for monoclonal antibodies (mAbs) is e
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Imaging is increasingly more utilized as analytical technology in biopharmaceutical formulation research, with applications ranging from subvisible particle characterization to thermal stability screening and residual moisture analysis. This review offers a comprehensive overview
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Image-based protein phase diagram analysis is key for understanding and exploiting protein phase behavior in the biopharmaceutical field. However, required data analysis has become a notorious time-consuming task since high-throughput screening approaches were implemented. A vari
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Abstract: Short-term parameters correlating to long-term protein stability, such as the protein cloud point temperature (Tcloud), are of interest to improve efficiency during protein product development. Such efficiency is reached if short-term parameters are obtained in a low vo
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Protein-based biopharmaceuticals require high purity before final formulation to ensure product safety, making process development time consuming. Implementation of computational approaches at the initial stages of process development offers a significant reduction in development
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Protein-based biopharmaceuticals require high purity before final formulation to ensure product safety, making process development time consuming. Implementation of computational approaches at the initial stages of process development offers a significant reduction in development
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Identification of long-term stable biopharmaceutical formulations is essential for biopharmaceutical product development. Reduction of the number of long-term storage experiments and a well-defined formulation search space requires knowledge-based formulation screenings and a det
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Identification of long-term stable biopharmaceutical formulations is essential for biopharmaceutical product development. Reduction of the number of long-term storage experiments and a well-defined formulation search space requires knowledge-based formulation screenings and a det
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Protein phase diagrams are a tool to investigate the cause and consequence of solution conditions on protein phase behavior. The effects are scored according to aggregation morphologies such as crystals or amorphous precipitates. Solution conditions affect morphologic features, s
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Protein phase diagrams are a tool to investigate the cause and consequence of solution conditions on protein phase behavior. The effects are scored according to aggregation morphologies such as crystals or amorphous precipitates. Solution conditions affect morphologic features, s
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The protein cloud-point temperature (TCloud) is a known representative of protein–protein interaction strength and provides
valuable information during the development and characterization of protein-based products, such as biopharmaceutics. A
high-throughput low volume TCloud
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The protein cloud-point temperature (TCloud) is a known representative of protein–protein interaction strength and provides
valuable information during the development and characterization of protein-based products, such as biopharmaceutics. A
high-throughput low volume TCloud
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Contributed
2 records found
Towards Holistic Science
Cultivating a mindset suiting inter- and transdisciplinarity
In the ever-changing landscape of the 21st century, complex issues like climate change demand holistic solutions. However, traditional scientific approaches often fall short by employing reductionism, breaking problems into isolated parts. This executive summary introduces a thes
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The traditional Eulerian view of biomass in bioprocess modelling results in issues when modelling large-scale bioreactors in which heterogeneous conditions are common. As the field increasingly moves from “scale-up” to “scale-down” philosophy, in which such heterogeneities are in
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