The full-spectrum white light-emitting diode (LED) emits light with a broad wavelength range by mixing all lights from multiple LED chips and phosphors. Thus, it has great potentials to be used in healthy lighting, high resolution displays, plant lighting with higher color rendering index close to sunlight and higher color fidelity index. The spectral power distribution (SPD) of light source, representing its light quality, is always dynamically controlled by complex electrical and thermal loadings when the light source operates under usage conditions. Therefore, a dynamic prediction of SPD for the full-spectrum white LED has become a hot but challenging research topic in the high quality lighting design and application. This paper proposes a dynamic SPD prediction method for the full-spectrum white LED by integrating the SPD decomposition approach with the artificial neural network (ANN) based machine learning method. Firstly, the continuous SPDs of a full-spectrum white LED driven by an electrical-thermal loading matrix are discretized by the multi-peak fitting with Gaussian model as the relevant spectral characteristic parameters. Then, the Back Propagation (BP) and Genetic Algorithm-Back Propagation (GA-BP) NNs are proposed to predict the spectral characteristic parameters of LEDs operated under any usage conditions. Finally, the dynamically predicted spectral characteristic parameters are used to reconstruct the SPDs. The results show that: (1) The spectral characteristic parameters obtained by fitting with the Gaussian model can be used to represent the emission lights from multiple chips and phosphors in a full-spectrum white LED; (2) The prediction errors of both BP NN and GA-BP NN can be controlled at low level, that is to say, our proposed method can achieve a highly accurate SPD dynamic prediction for the full-spectrum white LED when it operates under different operation mission profiles.@en