High density superconductor-semiconductor-superconductor junctions have a small induced superconducting gap due to the quasiparticle trajectories with a large momentum parallel to the junction having a very long flight time. Because a large induced gap protects Majorana modes, these long trajectories constrain Majorana devices to a low electron density. We show that a zigzag-shaped geometry eliminates these trajectories, allowing the robust creation of Majorana states with both the induced gap E_{gap} and the Majorana size ξ_{M} improved by more than an order of magnitude for realistic parameters. In addition to the improved robustness of Majoranas, this new zigzag geometry is insensitive to the geometric details and the device tuning.

Spin-orbit interaction (SOI) plays a key role in creating Majorana zero modes in semiconductor nanowires proximity coupled to a superconductor. We track the evolution of the induced superconducting gap in InSb nanowires coupled to a NbTiN superconductor in a large range of magnetic field strengths and orientations. Based on realistic simulations of our devices, we reveal SOI with a strength of 0.15-0.35 eV Å. Our approach identifies the direction of the spin-orbit field, which is strongly affected by the superconductor geometry and electrostatic gates.

Andreev bound states in hybrid superconductor-semiconductor devices can have near-zero energy in the topologically trivial regime as long as the confinement potential is sufficiently smooth. These quasi-Majorana states show zero-bias conductance features in a topologically trivial phase, mimicking spatially separated topological Majorana states. We show that in addition to the suppressed coupling between the quasi-Majorana states, also the coupling of these states across a tunnel barrier to the outside is exponentially different for increasing magnetic field. As a consequence, quasi-Majorana states mimic most of the proposed Majorana signatures: quantized zero-bias peaks, the 4π Josephson effect, and the tunneling spectrum in presence of a normal quantum dot. We identify a quantized conductance dip instead of a peak in the open regime as a distinguishing feature of true Majorana states in addition to having a bulk topological transition. Because braiding schemes rely only on the ability to couple to individual Majorana states, the exponential control over coupling strengths allows to also use quasi-Majorana states for braiding. Therefore, while the appearance of quasi-Majorana states complicates the observation of topological Majorana states, it opens an alternative route towards braiding of non-Abelian anyons and protected quantum computation.

We study the effects of strong coupling between a superconductor and a semiconductor nanowire on the creation of the Majorana bound states, when the quasiparticle dwell time in the normal part of the nanowire is much shorter than the inverse superconducting gap. This "short-junction" limit is relevant for the recent experiments using the epitaxially grown aluminum characterized by a transparent interface with the semiconductor and a small superconducting gap. We find that the small superconducting gap does not have a strong detrimental effect on the Majorana properties. Specifically, both the critical magnetic field required for creating a topological phase and the size of the Majorana bound states are independent of the superconducting gap. The critical magnetic field scales with the wire cross section, while the relative importance of the orbital and Zeeman effects of the magnetic field is controlled by the material parameters only: g factor, effective electron mass, and the semiconductor-superconductor interface transparency.

Junctions created by coupling two superconductors via a semiconductor nanowire in the presence of high magnetic fields are the basis for the potential detection, fusion, and braiding of Majorana bound states. We study NbTiN/InSb nanowire/NbTiN Josephson junctions and find that the dependence of the critical current on the magnetic field exhibits gate-tunable nodes. This is in contrast with a well-known Fraunhofer effect, under which critical current nodes form a regular pattern with a period fixed by the junction area. Based on a realistic numerical model we conclude that the Zeeman effect induced by the magnetic field and the spin-orbit interaction in the nanowire are insufficient to explain the observed evolution of the Josephson effect. We find the interference between the few occupied one-dimensional modes in the nanowire to be the dominant mechanism responsible for the critical current behavior. We also report a strong suppression of critical currents at finite magnetic fields that should be taken into account when designing circuits based on Majorana bound states.

We investigate the mechanistic nature of the Snf2 family protein HARP, mutations of which are responsible for Schimke immuno-osseous dysplasia. Using a single-molecule magnetic tweezers assay, we construct RPA-stabilized DNA bubbles within torsionally constrained DNA to investigate the annealing action of HARP on a physiologically relevant substrate. We find that HARP closes RPA-stabilized bubbles in a slow reaction, taking on the order of tens of minutes for ∼600 bp of DNA to be re-annealed. The data indicate that DNA re-anneals through the removal of RPA, which is observed as clear steps in the bubbleclosing traces. The dependence of the closing rate on both ionic strength and HARP concentration indicates that removal of RPA occurs via an association-dissociation mechanism where HARP does not remain associated with the DNA. The enzyme exhibits classical Michaelis-Menten kinetics and acts cooperatively with a Hill coefficient of 3 ± 1. Our work also allows the determination of some important features of RPA-bubble structures at low supercoiling, including the existence of multiple bubbles and that RPA molecules are mis-registered on the two strands.

Ballistic electron transport is a key requirement for existence of a topological phase transition in proximitized InSb nanowires. However, measurements of quantized conductance as direct evidence of ballistic transport have so far been obscured due to the increased chance of backscattering in one-dimensional nanowires. We show that by improving the nanowire-metal interface as well as the dielectric environment we can consistently achieve conductance quantization at zero magnetic field. Additionally we study the contribution of orbital effects to the sub-band dispersion for different orientation of the magnetic field, observing a near-degeneracy between the second and third sub-bands.

Studies of Majorana bound states in semiconducting nanowires frequently neglect the orbital effect of a magnetic field. Systematically studying its role leads us to several conclusions for designing Majoranas in this system. Specifically, we show that for experimentally relevant parameter values the orbital effect of a magnetic field has a stronger impact on the dispersion relation than the Zeeman effect. While Majoranas do not require the presence of only one dispersion subband, we observe that the size of the Majoranas becomes unpractically large, and the band gap unpractically small, when more than one subband is filled. Since the orbital effect of a magnetic field breaks several symmetries of the Hamiltonian, it leads to the appearance of large regions in parameter space with no band gap whenever the magnetic field is not aligned with the wire axis. The reflection symmetry of the Hamiltonian with respect to the plane perpendicular to the wire axis guarantees that the wire stays gapped in the topologically nontrivial region as long as the field is aligned with the wire.