The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system – Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.

In preterm infants, there is a risk of life-lasting impairments due to hemorrhagic/ischemic lesions. Our time-domain (TD) near-infrared optical tomography (NIROT) system “Pioneer” aims at detecting both disorders with high spatial resolution. Successfully tested on phantoms, “Pioneer” entered the phase of improvements and enhancements. The current probe (A-probe) was adapted for an optoacoustics instrument. A new probe (B-probe) optimized for TD measurements is required. Our aim is to determine the optimal arrangement of light sources in the B-probe to increase the sensitivity and the resolution of Pioneer and to improve the ability of the system to detect both ischemia and hemorrhage. To do this, we simulated TD-NIROT signals in NIRFAST, a MATLAB-based package used to model near-infrared light propagation through tissue. We used 16 × 16 detector array, with ~2.2 mm distance between the detectors. Light sources were arranged around the field of view (FoV). We performed forward simulations of light propagation through a “homogeneous case” (HC) tissue (μ′_s = 5.6 cm⁻¹, μ_a = 0.07 cm⁻¹). Next, we simulated light propagation through “inhomogeneous case” -tissue’ (IC) tissue by adding ischemia (μ_a = μ_a · 2.5 cm⁻¹) or hemorrhage (μ_a = μ_a · 50 cm⁻¹) to HT as a spherical inclusion of 5 mm radius at different depths in the FoV center and identified the source location that provides the higher contrast on the FoV: max_i ∈ I (FoVContrast_SOURCE). It was found that sources located closer to the FoV center generate greater contrast for late photons. This study suggests the light sources in B-probe should be closer to the FoV center. The higher sensitivity is expected to lead to a higher image quality.

A multipurpose monolithic array of 2 × 2 multichannel digital silicon photomultipliers (MD-SiPMs) fabricated in 40-nm CMOS technology is presented. Each MD-SiPM comprises 64 × 64 smart pixels connected to 128 low-power 45-ps sliding-scale time-to-digital converters (TDCs). The system can operate in two different modes: 1) event-driven and 2) frame-based. The first is suited for positron emission tomography (PET) and the second for synchronous applications like LiDAR. The design includes electronics to capture gamma events by means of a scintillator. The digital readout is fully embedded in the sensor and it is reconfigurable by SPI. Data packets are sent following a simple protocol compatible with an external FIFO, therefore making use of an FPGA optional. Every MD-SiPM can deliver up to 64M time-stamps/s. The sensor can be arranged in any type of configuration through a dedicated synchronization input and can be used to operate jointly with an event generator, such as a pulsed laser, which is useful in many applications. Inherently compatible with 3-D-stacking technology, the sensor can serve as front-end electronics when it is used with a different SPAD silicon tear.