FP
F. Pirim
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3 records found
1
Journal article
(2026)
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E. Aprea, F. Pirim, F.S. Stallone, Vasiliki Gkouzioti, Zhengwei Liao, L. Abelmann, J.P. Frimat, Pasqualina M Sarro, Clementine Boutry
Fully biodegradable microsystems enable therapies for temporary medical conditions that could not be addressed before. We present the first entirely biodegradable, wireless, implantable micropump for biomedical applications, with potential uses ranging from internal negative pressure wound therapy and drug delivery to soft robotics for temporary incontinence. As a proof-of-concept, the micropump was designed for peripheral nerve repair. It is magnetically actuated, featuring a nozzle/diffuser configuration, with a membrane of POMaC elastomer bonded to a magnetic POMaC/CIP composite. POMaC/CIP 20 wt% is selected for its mechanical and magnetic properties (Young’s modulus: 45 kPa, magnetic relative permeability: 1.14). A magnetic disc (6 mm x 0.5 mm) maximizes displacement and is actuated via a motor-driven magnetic setup at 4-8 Hz. An equivalent circuit model predicts under-pressure generation trends, confirmed experimentally through continuous/alternate pumping, repeatability assessments, and 240,000-cycle stability tests. In vitro and ex-vivo tests demonstrate consistent under-pressure (~2.3 kPa), meeting nerve regeneration requirements. Accelerated degradation tests show 31% mass loss after seven weeks, supporting short-term use. This platform is adaptable to diverse biomedical contexts, enabling novel therapies previously unachievable.
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Fully biodegradable microsystems enable therapies for temporary medical conditions that could not be addressed before. We present the first entirely biodegradable, wireless, implantable micropump for biomedical applications, with potential uses ranging from internal negative pressure wound therapy and drug delivery to soft robotics for temporary incontinence. As a proof-of-concept, the micropump was designed for peripheral nerve repair. It is magnetically actuated, featuring a nozzle/diffuser configuration, with a membrane of POMaC elastomer bonded to a magnetic POMaC/CIP composite. POMaC/CIP 20 wt% is selected for its mechanical and magnetic properties (Young’s modulus: 45 kPa, magnetic relative permeability: 1.14). A magnetic disc (6 mm x 0.5 mm) maximizes displacement and is actuated via a motor-driven magnetic setup at 4-8 Hz. An equivalent circuit model predicts under-pressure generation trends, confirmed experimentally through continuous/alternate pumping, repeatability assessments, and 240,000-cycle stability tests. In vitro and ex-vivo tests demonstrate consistent under-pressure (~2.3 kPa), meeting nerve regeneration requirements. Accelerated degradation tests show 31% mass loss after seven weeks, supporting short-term use. This platform is adaptable to diverse biomedical contexts, enabling novel therapies previously unachievable.
Conference paper
(2025)
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Elena Aprea, Francesco Stallone, Feyza Pirim-Aslan, Leon Abelmann, Pasqualina M. Sarro, Clementine Boutry
Peripheral Nerve Injury (PNI) leads to significant motor and sensory impairments, with limited recovery potential in injuries exceeding 3 cm, Conventional treatments often fail to achieve full functional restoration. Suction-based approaches at lesion sites have demonstrated promising outcomes in nerve regeneration. This work presents a novel wireless, magnetically actuated micropump composed of biodegradable materials, such as poly(octamethylene-maleate(anhydride)citrate) (POMaC), for nerve repair applications. The micropump integrates a magnetic ring within its membrane, enabling deflection under alternating magnetic field (4Hz,pm 150mT), generating a net under-pressure of 1.3 kPa within 8 minutes. It provides a potential solution to facilitate nerve healing.
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Peripheral Nerve Injury (PNI) leads to significant motor and sensory impairments, with limited recovery potential in injuries exceeding 3 cm, Conventional treatments often fail to achieve full functional restoration. Suction-based approaches at lesion sites have demonstrated promising outcomes in nerve regeneration. This work presents a novel wireless, magnetically actuated micropump composed of biodegradable materials, such as poly(octamethylene-maleate(anhydride)citrate) (POMaC), for nerve repair applications. The micropump integrates a magnetic ring within its membrane, enabling deflection under alternating magnetic field (4Hz,pm 150mT), generating a net under-pressure of 1.3 kPa within 8 minutes. It provides a potential solution to facilitate nerve healing.