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van Rooijen, W.A. (author), Hashemi, L. (author), Boon, M.M. (author), Farajzadeh, R. (author), Hajibeygi, H. (author)Underground Hydrogen Storage (UHS) is an attractive technology for large-scale (TWh) renewable energy storage. To ensure the safety and efficiency of the UHS, it is crucial to quantify the H<sub>2</sub> interactions with the reservoir fluids and rocks across scales, including the micro scale. This paper reports the experimental measurements...journal article 2022
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van Putten, R. (author), Eyke, Natalie S. (author), Baumgartner, L.M. (author), Schultz, Victor L. (author), Filonenko, G.A. (author), Jensen, Klavs F. (author), Pidko, E.A. (author)Automation and microfluidic tools potentially enable efficient, fast, and focused reaction development of complex chemistries, while minimizing resource- and material consumption. The introduction of automation-assisted workflows will contribute to the more sustainable development and scale-up of new and improved catalytic technologies....journal article 2022
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Neves Sao Pedro, M. (author), Silva dos Santos, M. (author), Eppink, Michel H.M. (author), Ottens, M. (author)A major challenge in the transition to continuous biomanufacturing is the lack of process analytical technology (PAT) tools which are able to collect real-time information on the process and elicit a response to facilitate control. One of the critical quality attributes (CQAs) of interest during monoclonal antibodies production is aggregate...journal article 2022
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Roy, Kaustav (author), Shastri, V.U. (author), Kumar, Akshay (author), Rout, Jagi (author), Isha, Isha (author), Kalyan, Kritank (author), Prakash, Jaya (author), Pratap, Rudra (author)We report on the development of a novel piezo-MEMS-based optofluidic platform to detect the concentration of various species dissolved in a fluid. This platform employs piezoelectric micromachined ultrasound transducers (PMUTs) to work as a photoacoustic receiver, receiving ultrasound from fluid targets present in microfluidic channels while...conference paper 2022
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Picanço Castanheira Da Silva, T. (author), Eppink, Michel (author), Ottens, M. (author)Biopharmaceuticals are becoming increasingly important in modern healthcare. Monoclonal antibodies (mAb) are one of the most widely used therapeutic proteins and are important for the treatment of cancer and autoimmune diseases, among others. After cell culture there are still large amounts of other impurities (e.g. host cell proteins) in...journal article 2022
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van Rooijen, Willemijn (author)Underground Hydrogen storage (UHS) is an attractive technology for large-scale energy storage. The UHS safety and efficiency depends highly on accurate characterization of H2 interactions with reservoir fluids, specially wettability analyses for H2/brine/rock systems. This thesis reports experimental measurements of advancing and receding...master thesis 2021
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Totlani, K. (author)A crucial challenge during the initial stages of bioprocess development is that tools used to screen microorganisms and optimize cultivation conditions do not represent the environment imposed at industrial scale. Inside an industrial-scale bioreactor, microorganisms are often cultivated under fed-batch conditions, where nutrients are supplied...doctoral thesis 2021
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van Altena, Pieter (author)Facioscapulohumeral muscle dystrophy (FSHD) is the third most common muscle disease in the world. No cure has been found for FSHD, and current treatments focus on alleviating the symptoms. The disease is caused by a genetic error in 1/1000 - 1/200 of the nuclei in a multinucleated skeletal muscle cell. Studying that specific nucleus, by removing...master thesis 2021
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Dekker, Levi (author)In this thesis, a ground structure based thermofluid topology optimization (TO) method is presented which is applicable to problems with creeping flow. Fluid channels with creeping flow are found in a variety of engineering applications, primarily in the field of microfluidics. Current fluid channel TO is typically done with density-based TO and...master thesis 2021
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Kumar, Sowmya (author)The coalescence of two droplets suspended in a viscous fluid is the focus of this study. When two droplets that are suspended in a shearing flow come in contact with each other, it is currently uncertain if the contact would result in coalescence. To be able to make such predictions, it is necessary to study the effects of the system parameters,...master thesis 2021
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Robben, Stijn (author)Predicting the effects of drugs before human clinical trails is at the heart of drug discovery and screening processes. To overcome limitations of conventional models used in pre-clinical research stages, advancements in fabrication, microfluidics, tissue engineering and sensor development allow for platforms that ever more closely emulate human...master thesis 2021
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van Reeuwijk, Matthijs (author)Current technology of Organ-on-Chips allows investigation of human cells outside the body including a microfluidic medium flow. Control of oxygen in this microfluidic flow is required to mimic the situation as in the human liver (physiological) or to create temporary low oxygen concentrations (hypoxia). In this research, a gas exchanger module...master thesis 2021
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Paardekooper, Stijn (author)Any resonance based sensing method such as AFM or mass sensing using microfluidic cantilevers require high frequency stability. For mass measurement, a stable frequency allows for a lower mass resolution. One of the most commonly used methods to actuate these resonators is using piezoacoustics. A major downside of this method is the presence of...master thesis 2021
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Eijkel, Dirk (author)In the last two decades, it has been generally accepted that the interaction between bone and immune cells is critical in the process of bone healing and regeneration. Steering this immune response with the development of biomaterials could lead to implant acceptance in the long term. The understanding of osteoimmunological responses is of high...master thesis 2021
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Aalbers, Sarah (author)The Organ on Chip (OoC) market is fast-growing and has the promise to drastically reduce the cost of developing drugs and the need for animal testing. However, the growth could be obstructed by the difficulties of scaling up production of developed prototypes. Most OoC prototypes are not suited for mass production because of the material used,...master thesis 2021
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Shriya Rangaswamy, Shriya (author)The lack of reliable disease models hampers the development of safe and effective drugs for humansas they fail to precisely identify the cardiotoxicity profile of drug compounds. Recent technological advancements have led to the development of the"Organ-On-Chip"(OOC) technology. OOCs are miniaturized micro-engineered devices which aim to...master thesis 2021
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Mollaie Daryani, Mehdi (author)In connection with growing in applications of nanoparticles in various industrial sectors such as cosmetics and pharmaceuticals, the demand for in-line identification and characterization of nanoparticles suspended in fluids has increased. In addition to that, nanoparticles in general and nanoplastics in particular, can easily contaminate air...master thesis 2021
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Neves Sao Pedro, M. (author), Klijn, M.E. (author), Eppink, Michel H.M. (author), Ottens, M. (author)The transition to continuous biomanufacturing is considered the next step to reduce costs and improve process robustness in the biopharmaceutical industry, while also improving productivity and product quality. The platform production process for monoclonal antibodies (mAbs) is eligible for continuous processing to lower manufacturing costs...review 2021
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Amador, G.J. (author), van Dijk, Dennis (author), Kieffer, R.Y. (author), Aubin-Tam, M.E. (author), Tam, D.S.W. (author)Vital biological processes, such as trafficking, sensing, and motility, are facilitated by cellular lipid membranes, which interact mechanically with surrounding fluids. Such lipid membranes are only a few nanometers thick and composed of a liquid crystalline structure known as the lipid bilayer. Here, we introduce an active, noncontact, two...journal article 2021
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Picanço Castanheira Da Silva, T. (author), Eppink, Michel (author), Ottens, M. (author)Process development in the biotech industry leads to investments around hundred of millions of dollars. It is important to mitigate costs without neglecting the quality of process development. Biopharmaceutical process development is important for companies to develop new processes and be first to market, improve a pre-established process, or...review 2021