Solder joint failure is one of the most common board-level failure modes in electronic components. It is crucial for a next-generation reliability assessment method to have an in-situ health monitoring system in place to evaluate the current state of degradation. This is achieved by specialized embedded sensors and processing the data on the edge. This study focuses on monitoring the mechanical degradation of package-to-PCB solder interconnects of a WLCSP using a high-resolution piezoresistive sensor. First, a measurement workflow was set up to optimize and significantly improve the sensor readout time. Then, utilizing a design of experiments, the test specimens were subjected to certain combinations of mechanical and thermal loads in a four-point bending setup. Temperature-coupled mechanical loading showed a greater impact on the resulting stress pattern compared to that of a superposition of the corresponding individual purely thermal and mechanical load configurations. Finally, the specimens were tested under a purely mechanical load until failure, and a correlation between the recorded stress pattern and the initiation and propagation of a crack was established.@en