GB

G.A. Bouland

12 records found

Alzheimer's Disease (AD) is a complex heterogeneous disease and is the leading cause of dementia around the world. Treatment options remain limited and the underlying mechanisms are not yet fully understood. To get more insight on this celular level, single-cell gene expression d ...
The aim of this research is to investigate whether physical gene characteristics can predict age-related changes in gene expression. Specifically, we analyze gene length, GC content, distance to the ends of the chromosome, and similar features to determine their connection with d ...
Single-cell RNA sequencing (scRNAseq) is a measuring technique of gene expressions in single cells that has allowed researchers to tackle Alzheimer’s disease (AD) in many ways. Single-cell data has been joined with machine learning to classify brain cells as affected by AD. Howev ...

Improving Single-Cell Transcriptomic Aging Clocks

Enhancing Accuracy and Biological Interpretability

Biological aging clocks estimate age from molecular data and provide insights into age-related functional decline. While aging clocks based on bulk transcriptomic data are well-studied, their single-cell counterparts remain limited and underexplored. In this study, we replicate a ...
Aging is the biological process that changes the body over time. When we age our bodies become more prone to disease and other health risks. But not everyone experiences these changes at the same age. This is because the age of our cells (biological age) does not always match our ...

Binarized single cell RNA sequencing data clustering

The impact of binarized scRNA-seq data on clustering through community detection algorithms

Single-cell RNA sequencing data clustering is a valuable technique for demonstrating cell-to-cell heterogeneity and revealing cell dynamics within and amongst groups. Large up-scaling of scRNA-seq datasets in recent years pose computational challenges for existing state-of-the-ar ...

Memory usage analysis of binary clustering algorithm

What is the gain in peak memory usage of the binary clustering algorithm compared to current state-of-the-art clustering methods?

The rapid increase in the size of single-cell RNAseq datasets presents significant performance challenges when conducting evaluations and extracting information. We research an alternative input data format that utilizes binarization. Our main focus is an analysis of peak memory ...
As single-cell RNA sequencing techniques improve and more cells are measured in individual experiments, cell clustering procedures become increasingly more computationally intensive. This paper studies the runtime performance impact of a specialized clustering algorithm for data ...

Similarity metrics for binary cell clustering

How close can we get to state-of-the-art ?

Analysing single-cell RNA sequencing data is becoming an increasingly tedious task as the size of data sets grows. As a proposed solution, recent discoveries suggest that these data sets can be binarized without losing much information. This in turn should allow for memory and ti ...
Understanding the role of genes and genetic variants is a key challenge in unraveling the driving mechanisms of Alzheimer's disease (AD). Single-cell RNA sequencing is a technique that quantifies gene expression at the cell (type) level enabling investigation of the roles of diff ...