Person | TU Delft Repository

Hemodynamic Study of a Patient-Specific Intracranial Aneurysm

Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics

Journal article - X. Wu, X. Wu, S.D. Gurzing, C.V. Schinkel, Merel Toussaint, R. Perinajová, P van Ooij, S. Kenjeres, S. Kenjeres

Introduction: Wall shear stress (WSS) is associated with the growth and rupture of an intracranial aneurysm. To reveal their underlying connections, many image-based computational fluid dynamics (CFD) studies have been conducted. However, the methodological validations using both ...

Modeling of blood flow in aorta

MRI-based computational fluid dynamics of aortic hemodynamics

Doctoral thesis - R. Perinajová

Aortic aneurysm, a balloon-like enlargement of the healthy artery, is a cardiovascular disease with one of the highest mortality rates. These numbers are due to the usual late diagnosis of the aneurysm, which is often asymptomatic until a fatal event occurs. Such an event can pro ...

Flow patterns in ascending aortic aneurysms

Determining the role of hypertension using phase contrast magnetic resonance and computational fluid dynamics

Journal article - M. J.F.G. Ramaekers, I.B. van der Vlugt, Jos Westenberg, R. Perinajová, R. Perinajová, Hildo Lamb, Joachim E. Wildberger, S. Kenjeres, Simon Schalla

Thoracic aortic aneurysm (TAA) is a local dilation of the thoracic aorta. Although universally used, aneurysm diameter alone is a poor predictor of major complications such as rupture. There is a need for better biomarkers for risk assessment that also reflect the aberrant flow p ...

Thoracic aortic aneurysm (TAA) is a local dilation of the thoracic aorta. Although universally used, aneurysm diameter alone is a poor predictor of major complications such as rupture. There is a need for better biomarkers for risk assessment that also reflect the aberrant flow patterns found in TAAs. Furthermore, hypertension is often present in TAA patients and may play a role in progression of aneurysm. The exact relation between TAAs and hypertension is poorly understood. This study aims to create a numerical model of hypertension in the aorta by using computational fluid dynamics. First, a normotensive state was simulated in which flow and resistance were kept unaltered. Second, a hypertensive state was modeled in which blood inflow was increased by 30%. Third, a hypertensive state was modeled in which the proximal and peripheral resistances and capacitance parameters from the three-element Windkessel boundary condition were adjusted to mimic an increase in resistance of the rest of the cardiovascular system. One patient with degenerative TAA and one healthy control were successfully simulated at hypertensive states and were extensively analyzed. Furthermore, three additional TAA patients and controls were simulated to validate our method. Hemodynamic variables such as wall shear stress, oscillatory shear index, endothelial cell activation potential (ECAP), vorticity and helicity were studied to gain more insight on the effects of hypertension on flow patterns in TAAs. By comparing a TAA patient and a control at normotensive state at peak-systole, helicity and vorticity were found to be lower in the TAA patient throughout the entire domain. No major changes in flow and flow derived quantities were observed for the TAA patient and control when resistance was increased. When flow rate was increased, regions with high ECAP values were found to reduce in TAA patients in the aneurysm region which could reduce the risk of thrombogenesis. Thus, it may be important to assess cardiac output in patients with TAA.@en

Flow patterns in ascending aortic aneurysms

Determining the role of hypertension using phase contrast magnetic resonance and computational fluid dynamics

Journal article - M. J.F.G. Ramaekers, I.B. van der Vlugt, Jos Westenberg, R. Perinajová, R. Perinajová, Hildo Lamb, Joachim E. Wildberger, S. Kenjeres, Simon Schalla

Thoracic aortic aneurysm (TAA) is a local dilation of the thoracic aorta. Although universally used, aneurysm diameter alone is a poor predictor of major complications such as rupture. There is a need for better biomarkers for risk assessment that also reflect the aberrant flow p ...

Thoracic aortic aneurysm (TAA) is a local dilation of the thoracic aorta. Although universally used, aneurysm diameter alone is a poor predictor of major complications such as rupture. There is a need for better biomarkers for risk assessment that also reflect the aberrant flow patterns found in TAAs. Furthermore, hypertension is often present in TAA patients and may play a role in progression of aneurysm. The exact relation between TAAs and hypertension is poorly understood. This study aims to create a numerical model of hypertension in the aorta by using computational fluid dynamics. First, a normotensive state was simulated in which flow and resistance were kept unaltered. Second, a hypertensive state was modeled in which blood inflow was increased by 30%. Third, a hypertensive state was modeled in which the proximal and peripheral resistances and capacitance parameters from the three-element Windkessel boundary condition were adjusted to mimic an increase in resistance of the rest of the cardiovascular system. One patient with degenerative TAA and one healthy control were successfully simulated at hypertensive states and were extensively analyzed. Furthermore, three additional TAA patients and controls were simulated to validate our method. Hemodynamic variables such as wall shear stress, oscillatory shear index, endothelial cell activation potential (ECAP), vorticity and helicity were studied to gain more insight on the effects of hypertension on flow patterns in TAAs. By comparing a TAA patient and a control at normotensive state at peak-systole, helicity and vorticity were found to be lower in the TAA patient throughout the entire domain. No major changes in flow and flow derived quantities were observed for the TAA patient and control when resistance was increased. When flow rate was increased, regions with high ECAP values were found to reduce in TAA patients in the aneurysm region which could reduce the risk of thrombogenesis. Thus, it may be important to assess cardiac output in patients with TAA.@en

Flow patterns in ascending aortic aneurysms

Determining the role of hypertension using phase contrast magnetic resonance and computational fluid dynamics

Journal article - M. J.F.G. Ramaekers, I.B. van der Vlugt, Jos Westenberg, R. Perinajová, R. Perinajová, Hildo Lamb, Joachim E. Wildberger, S. Kenjeres, Simon Schalla

Thoracic aortic aneurysm (TAA) is a local dilation of the thoracic aorta. Although universally used, aneurysm diameter alone is a poor predictor of major complications such as rupture. There is a need for better biomarkers for risk assessment that also reflect the aberrant flow p ...

Thoracic aortic aneurysm (TAA) is a local dilation of the thoracic aorta. Although universally used, aneurysm diameter alone is a poor predictor of major complications such as rupture. There is a need for better biomarkers for risk assessment that also reflect the aberrant flow patterns found in TAAs. Furthermore, hypertension is often present in TAA patients and may play a role in progression of aneurysm. The exact relation between TAAs and hypertension is poorly understood. This study aims to create a numerical model of hypertension in the aorta by using computational fluid dynamics. First, a normotensive state was simulated in which flow and resistance were kept unaltered. Second, a hypertensive state was modeled in which blood inflow was increased by 30%. Third, a hypertensive state was modeled in which the proximal and peripheral resistances and capacitance parameters from the three-element Windkessel boundary condition were adjusted to mimic an increase in resistance of the rest of the cardiovascular system. One patient with degenerative TAA and one healthy control were successfully simulated at hypertensive states and were extensively analyzed. Furthermore, three additional TAA patients and controls were simulated to validate our method. Hemodynamic variables such as wall shear stress, oscillatory shear index, endothelial cell activation potential (ECAP), vorticity and helicity were studied to gain more insight on the effects of hypertension on flow patterns in TAAs. By comparing a TAA patient and a control at normotensive state at peak-systole, helicity and vorticity were found to be lower in the TAA patient throughout the entire domain. No major changes in flow and flow derived quantities were observed for the TAA patient and control when resistance was increased. When flow rate was increased, regions with high ECAP values were found to reduce in TAA patients in the aneurysm region which could reduce the risk of thrombogenesis. Thus, it may be important to assess cardiac output in patients with TAA.@en

On the identification of hypoxic regions in subject-specific cerebral vasculature by combined CFD/MRI

Journal article - R. Perinajová, R. Perinajová, P van Ooij, S. Kenjeres, S. Kenjeres

A long-time exposure to lack of oxygen (hypoxia) in some regions of the cerebrovascular system is believed to be one of the causes of cerebral neurological diseases. In the present study, we show how a combination of magnetic resonance imaging (MRI) and computational fluid dynami ...

Influence of aortic aneurysm on the local distribution of NO and O<sub>2</sub> using image-based computational fluid dynamics

Journal article - R. Perinajová, R. Perinajová, Concepción Borrás Álvarez-Cuevas, Joe F. Juffermans, Jos Westenberg, Hildo Lamb, S. Kenjeres, S. Kenjeres

There is a pressing need to establish novel biomarkers to predict the progression of thoracic aortic aneurysm (TAA) dilatation. Aside from hemodynamics, the roles of oxygen (O2) and nitric oxide (NO) in TAA pathogenesis are potentially significant. As such, it is imperative to co ...

Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations

Journal article - R. Perinajová, R. Perinajová, J.F. Juffermans, Jonhatan Lorenzo Mercado, Jean Paul Aben, Leon Ledoux, Jos Westenberg, Hildo Lamb, S. Kenjeres, S. Kenjeres

In this study, we analyzed turbulent flows through a phantom (a 180∘ bend with narrowing) at peak systole and a patient-specific coarctation of the aorta (CoA), with a pulsating flow, using magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). For MRI, a 4D-flo ...

Geometrically induced wall shear stress variability in CFD-MRI coupled simulations of blood flow in the thoracic aortas

Journal article - R. Perinajová, Joe F. Juffermans, Jos Westenberg, Roel L.F. van der Palen, Pieter Van Den Boogaard, Hildo Lamb, S. Kenjeres

Aortic aneurysm is associated with aberrant blood flow and wall shear stress (WSS). This can be studied by coupling magnetic resonance imaging (MRI) with computational fluid dynamics (CFD). For patient-specific simulations, extra attention should be given to the variation in segm ...

R. Perinajová

Authored

Hemodynamic Study of a Patient-Specific Intracranial Aneurysm

Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics

Modeling of blood flow in aorta

MRI-based computational fluid dynamics of aortic hemodynamics

Flow patterns in ascending aortic aneurysms

Determining the role of hypertension using phase contrast magnetic resonance and computational fluid dynamics

Flow patterns in ascending aortic aneurysms

Determining the role of hypertension using phase contrast magnetic resonance and computational fluid dynamics

Flow patterns in ascending aortic aneurysms

Determining the role of hypertension using phase contrast magnetic resonance and computational fluid dynamics

On the identification of hypoxic regions in subject-specific cerebral vasculature by combined CFD/MRI

Influence of aortic aneurysm on the local distribution of NO and O<sub>2</sub> using image-based computational fluid dynamics

Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations

Geometrically induced wall shear stress variability in CFD-MRI coupled simulations of blood flow in the thoracic aortas

Contributed

Numerical Analysis on Hemodynamics in Intracranial Aneurysms

Proposing a third hemodynamic criterion for predicting rupture sites