Introduction: In 2012, potassium and sodium ion channels in Hodgkin-Huxley-based brain models were shown to exhibit memristive behavior. This positioned memristors as strong candidates for implementing biologically accurate artificial neurons. Memristor-based brain simulations offer advantages in energy efficiency, scalability, and compactness, benefiting fields such as soft robotics, embedded systems, and neuroprosthetics. Methods: Previous approaches used current-controlled Mott memristors, which poorly matched the voltage-controlled nature of ion channels. This study employs volatile, oxide-based memristors that leverage electric-field-driven oxygen-vacancy migration to emulate voltage-dependent channel behavior. We selected candidate WOx and NbOx memristors and modeled their dynamics to verify performance as Hodgkin-Huxley potassium channels. Results: The device exhibits sigmoidal gating and voltage-dependent time constants consistent with the theoretical model. By scaling the passive circuitry around the memristors, we show that they capture the essential mechanisms of potassium ion-channels, although spike height is reduced due to strong non-linear voltage-dependence. Still, by cascading multiple compartments, typical spike propagation is retained. Discussion: This is the first demonstration of a voltage-controlled memristor replicating the Hodgkin-Huxley potassium channel, validating its potential for more efficient brain simulation hardware.

Computational-neuroscience research is increasingly in need of larger, biophysically realistic brain models. These analog-in-nature models build upon the Hodgkin-Huxley (HH) formalism and are run on digital, high-performance computing systems making simulation very computationally expensive. In circuit form, these models are theoretically suitable for efficient analog implementation. However, the ion-channel components –predominantly, sodium and potassium– are nonlinear, time-varying resistors, lacking an efficient implementation. Chua et al. proved that these ion-channel models are in fact memristors –devices with a conductance as a function of applied-voltage history– claiming that “memristors are the right stuff for building brains”. However, the kind of actual memristor implementation that is the right one for building brains is not defined. In this article, the device class and characteristics of such memristors are defined and existing memristive implementations of HH-like designs are then reviewed. Surprisingly, although often misclassified as such, no physical implementation currently exists that replicates the original HH equations faithfully or efficiently. Having put forward the desired memristor properties, a design guide for screening suitable memristor designs is then proposed. Screening the existing literature reveals that suitable devices likely already exist for potassium ion-channel emulation, while none exists for sodium; this calls for further investigation of higher-order, voltage-controlled and volatile memristors.

Brain modeling can occur at different levels of abstraction, each aimed at a different purpose. The Virtual Brain (TVB) is an open-source platform for constructing and simulating personalized brain-network models, favoring whole-brain macro-scales while reducing micro-level detail. Among other purposes, TVB is used to build patient-specific, digital, brain twins that can be used in different clinical settings, such as the study and treatment of epilepsy. However, fitting patient-specific TVB models requires a large number of successive and time-consuming simulations. By studying the internal structure of TVB, we observed heterogeneous computation needs in its models which could be leveraged to accelerate simulations. In this work, we designed and implemented HUMA, a heterogeneous, ultra low-latency, dataflow architecture on an AMD Versal Adaptive SoC to accelerate TVB fitting to different patient-brain makeups. Our heterogeneous solution runs about 27× faster compared to a modern-day, server-class, 32-core CPU while consuming a fraction of its power. Additionally, it delivers on average about 14× lower latency, 1.7× better power efficiency and an order-of-magnitude lower energy consumption when compared against the high-performance GPU version of TVB. The achieved latency savings reveal a significant potential in model-fitting for individual patients as well as in closed-loop biohybrid experiments.

Olivocerebellar learning is highly adaptable, unfolding over minutes to weeks depending on the task. However, the stabilizing mechanisms of the synaptic dynamics necessary for ongoing learning remain unclear. We constructed a model to examine plasticity dynamics under stochastic input and investigate the impact of inferior olive (IO) reverberations on Purkinje cell (PCs) activity and synaptic plasticity. We explored Upbound and Downbound cerebellar micromodules, which are organized loops of IO neurons, cerebellar nuclei neurons and microzones of PCs characterized by their unique molecular profiles and different levels of baseline firing. Our findings show synaptic weight convergence followed by stability of synaptic weights. In line with their relatively low and high intrinsic firing, we observed that Upbound and Downbound PCs have a propensity for potentiation and depression, respectively, with both PC types reaching stability at differential levels of overall strength of their parallel-fiber (PF) inputs. The oscillations and coupling of IO neurons participating in the Upbound and Downbound modules determine at which frequency band PFs can be stabilized optimally. Our results indicate that specific frequency components drive IO resonance and synchronicity, which, in turn, regulate temporal patterning across Upbound and Downbound zones, orchestrating their plasticity dynamics.

In recent years, significant strides in Artificial Intelligence (AI) have led to various practical applications, primarily centered around training and deployment of deep neural networks (DNNs). These applications, however, require considerable computational resources, predominantly reliant on modern Graphics-Processing Units (GPUs). Yet, the quest for larger and faster DNNs has spurred the creation of specialized AI chips and efficient Machine-Learning (ML) software tools like TensorFlow and PyTorch have been developed for striking a balance between usability and performance. Simultaneously, the field of computational neuroscience shares a similar quest for increased computational power to simulate more extensive and detailed brain models, while also keeping usability high. Although GPUs have also entered this field, programming complexity remains high, resulting in cumbersome simulations. Inspired by AI progress, we introduce a workflow for easily accelerating brain simulations using TensorFlow and evaluate the performance of various, cutting-edge AI chips – including the Graphcore Intelligence-Processing Unit (IPU), GroqChip, Nvidia GPU with Tensor Cores, and Google Tensor-Processing Unit (TPU) – when simulating a biologically detailed as well as simpler brain models. Our model simulations explore the architectural tradeoffs of a modern-day CPU and these four AI platforms by varying computational density, memory requirements and floating-point numerical accuracy. Results show that the GroqChip achieves the best performance for small networks, yet is unable to simulate large-scale networks. At the scale of mammalian brains, the GPU, IPU and TPU achieve speedups ranging from 29x to 1,208x times over CPU runtimes. Remarkably, the TPU sets a new record for the largest, real-time simulation of the inferior-olivary nucleus in the brain. Reduced-accuracy floating-point implementations make some simulation results unreliable for brain research, notably for the GroqChip. Consequently, this work underscores the potential of ML libraries for accelerating brain simulations as well as the critical role of AI-chip numerical accuracy for biophysically realistic brain models.

Electrophysiological recordings of neural activity in a mouse's brain are very popular among neuroscientists for understanding brain function. One particular area of interest is acquiring recordings from the Purkinje cells in the cerebellum in order to understand brain injuries and the loss of motor functions. However, current setups for such experiments do not allow the mouse to move freely and, thus, do not capture its natural behaviour since they have a wired connection between the animal's head stage and an acquisition device. In this work, we propose a lightweight neuronalspike detection and classification architecture that leverages on the unique characteristics of the Purkinje cells to discard unneeded information from the sparse neural data in real time. This allows the (condensed) data to be easily stored on a removable storage device on the head stage, alleviating the need for wires. Synthesis results reveal a >95% overall classification accuracy while still resulting in a small-form-factor design, which allows for the free movement of mice during experiments. Moreover, the power-efficient nature of the design and the usage of STT-RAM (Spin Transfer Torque Magnetic Random Access Memory) as the removable storage allows the head stage to easily operate on a tiny battery for up to approximately 4 days.