Z. Roosenboom-Kwee
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24 records found
1
Decentralized Autonomous Organizations
Organizational Opportunities and Governance Challenges
Decentralized autonomous organizations in the public sector
Opportunities and risks
Climate change may influence tuberculosis (TB) transmission through environmental and health system pathways. It is important to understand how the health system can adapt to reduce the impact of climate change on TB transmission.
Methods
We conducted an ecological study using district-level data from the Indonesian Health Facility Research Survey, the National Health Insurance data sample registry, and monthly climate indicators (temperature, humidity, precipitation) for 2019. Mediation analysis was applied to assess the role of healthcare preparedness in mediating the relationship between climatic variability and TB incidence.
Results
Healthcare preparedness fully mediated the association between humidity and TB incidence. The indirect effect through healthcare preparedness was statistically significant (α × β = 0.0021, 95% CI: 0.0008, 0.0035), while the direct effect was not (c1 = 0.0102, 95% CI: -0.0013, 0.0217). Approximately 17.1% of the total effect of humidity on TB (c = 0.0123, 95% CI: 0.0009, 0.0237) mediated through healthcare preparedness. For temperature, the relationship with TB was partially mediated, with a small but significant negative indirect effect (α × β = -0.0002, 95% CI: -0.0003, -0.0001), indicating that adequate healthcare may offset about 14.3% of temperature-related TB risk, while a significant direct effect remained. No significant mediation was found for precipitation.
Conclusion
These findings highlight the importance of targeted investments to strengthen healthcare systems in high-burden, climate-vulnerable districts. Integrating climate adaptation into TB control programs and enhancing surveillance are essential to ensure accurate burden estimation, effective resource allocation, and resilience against the combined challenges of climate variability and TB transmission. ...
Climate change may influence tuberculosis (TB) transmission through environmental and health system pathways. It is important to understand how the health system can adapt to reduce the impact of climate change on TB transmission.
Methods
We conducted an ecological study using district-level data from the Indonesian Health Facility Research Survey, the National Health Insurance data sample registry, and monthly climate indicators (temperature, humidity, precipitation) for 2019. Mediation analysis was applied to assess the role of healthcare preparedness in mediating the relationship between climatic variability and TB incidence.
Results
Healthcare preparedness fully mediated the association between humidity and TB incidence. The indirect effect through healthcare preparedness was statistically significant (α × β = 0.0021, 95% CI: 0.0008, 0.0035), while the direct effect was not (c1 = 0.0102, 95% CI: -0.0013, 0.0217). Approximately 17.1% of the total effect of humidity on TB (c = 0.0123, 95% CI: 0.0009, 0.0237) mediated through healthcare preparedness. For temperature, the relationship with TB was partially mediated, with a small but significant negative indirect effect (α × β = -0.0002, 95% CI: -0.0003, -0.0001), indicating that adequate healthcare may offset about 14.3% of temperature-related TB risk, while a significant direct effect remained. No significant mediation was found for precipitation.
Conclusion
These findings highlight the importance of targeted investments to strengthen healthcare systems in high-burden, climate-vulnerable districts. Integrating climate adaptation into TB control programs and enhancing surveillance are essential to ensure accurate burden estimation, effective resource allocation, and resilience against the combined challenges of climate variability and TB transmission.
Exploring Synergies
Comparative analysis of technology assessment and RRI in European industrial contexts
Strategic leadership and ubiquitous ambient intelligence
A new approach to reconcile exploitation and exploration in the Fourth Industrial Revolution?
Prisma
A standard to go beyond the status quo and roadmaps to innovate responsibly
This chapter discusses principles, frameworks, and steps for designing a roadmap to implement Responsible Research and Innovation (RRI) in industrial practices. It is based on invaluable experience gathered from the EU-funded PRISMA project, in which a trans-disciplinary group of experts from research, industries, and policy developed guidelines to include relevant societal values in the development strategy of innovative products. These guidelines are built on existing corporate social responsibility (CSR) and quality, risk and innovation management standards and policies. Fundamentally, they provide a management standard (Plan-Do-Check-Act cycle) that could help companies to introduce structural changes in their usual business practices toward more anticipatory, inclusive, and RRI practices (responsibility-by-design). The guidelines can be used by researchers, businesses, and innovators to develop long-term strategies (roadmaps) for Responsible Innovation, which, in turn, help organizations identify and achieve technologies geared toward ethically and socially desirable outcomes.
The ins and outs of decentralized autonomous organizations (DAOs)
Unraveling the definitions, characteristics, and emerging developments of DAOs
Unleashing Domestic Firms' Potential to Innovate
The case of ICT in Indonesia
Governance impacts of blockchain-based decentralized autonomous organizations
An empirical analysis
Responsible research and innovation in practice
An exploratory assessment of Key Performance Indicators (KPIs) in a Nanomedicine Project
Blockchain in Service Management and Service Research
Developing a Research Agenda and Managerial Implications
A Roadmap for Responsible Innovation in Industries
Incorporating ethical and societal values
There is now almost a decade of experience with RRI (Responsible Research and Innovation), including a growing emphasis on RRI in industry. Based on our experiences in the EU-funded project PRISMA, we find that the companies we engaged could be motivated to do RRI, but often only after we first shifted initial assumptions and strategies. Accordingly, we formulate six lessons we learned in the expectation that they will be relevant both for RRI in industry as well as for the future of RRI more broadly. These lessons are: (1) Strategize for stakeholder engagement; (2) Broaden current assessments; (3) Place values center stage; (4) Experiment for responsiveness; (5) Monitor RRI progress; and (6) Aim for shared value.
of different layers (infrastructure, application, company and institution/country) and stages (design, operate, evolve/crisis). The results show that in various stages and layers, different challenges occur. Furthermore, blockchain applications governance and blockchain infrastructure governance were found to be entangled adding to the challenge. Our research shows a specific need
for further research into governance models for DAO applications on permissionless blockchains, linked to the products and services offered whereas in permissioned blockchains and other type of applications, existing governance models might often be feasible. For developing new governance models, we recommend learning from the lessons from the open source community. ...
of different layers (infrastructure, application, company and institution/country) and stages (design, operate, evolve/crisis). The results show that in various stages and layers, different challenges occur. Furthermore, blockchain applications governance and blockchain infrastructure governance were found to be entangled adding to the challenge. Our research shows a specific need
for further research into governance models for DAO applications on permissionless blockchains, linked to the products and services offered whereas in permissioned blockchains and other type of applications, existing governance models might often be feasible. For developing new governance models, we recommend learning from the lessons from the open source community.