This article presents an application-specific integrated circuit (ASIC) for catheter-based 3-D ultrasound imaging probes. The pitch-matched design implements a comprehensive architecture with high-voltage (HV) transmitters, analog front ends, hybrid beamforming analog-To-digital converters (ADCs), and data transmission to the imaging system. To reduce the number of cables in the catheter while maintaining a small footprint per element, transmission (TX) beamforming is realized on the chip with a combination of a shift register (SR) and a row/column (R/C) approach. To explore an additional cable-count reduction in the receiver part of the design, a channel with a combination of time-division multiplexing (TDM), subarray beamforming, and multi-level pulse amplitude modulation (PAM) data transmission is also included. This achieves an 18-fold cable-count reduction and minimizes the power consumption in the catheter by a load modulation (LM) cable driver. It is further explored how common-mode interference can limit beamforming gain and a strategy to reduce its impact with local regulators is discussed. The chip was fabricated in TSMC 0.18-m HV BCD technology and a 2-D PZT transducer matrix of 16 × 18 elements with a pitch of 160 m and a center frequency of 6 MHz was manufactured on the chip. The system can generate all required TX patterns at up to 30 V, provides quick settling after the TX phase, and has an reception (RX) power consumption of only 1.12 mW/element. The functionality and operation of up to 1000 volumes/s have been demonstrated in electrical and acoustic imaging experiments.@en

Over the past decades, real-time three-dimensional (3D) medical ultrasound has attracted much attention since it enables clinicians to diagnose more accurately. This calls for ultrasound matrix transducers with a large number of elements, which can be interfaced with an application-specific integrated circuit (ASIC) for data reduction. An important aspect of the design of such a transducer is the geometry of each element, since it affects the mode of vibration and, consequently, the efficiency of the transducer. In this paper, we experimentally investigate the effect of subdicing on a piezoelectric (PZT) transducer. We fabricate and acoustically characterize a prototype PZT matrix transducer built on top of ASICs. The prototype transducer contains subdiced and non-subdiced elements, whose performance can be directly compared under the same conditions. Measurement results show that subdiced elements have a better performance compared to non-subdiced ones. Subdicing increases the peak pressure by 25%, raises the bandwidth by 10% and reduces the ringing time by 25%.@en

Over the past decades, ultrasound imaging has made considerable progress based on the advancement of imaging systems as well as transducer technology. With the need for advanced transducer arrays with complex designs and technical requirements, there is also a need for suitable tools to characterize such transducers. However, despite the importance of acoustic characterization to assess the performance of novel transducer arrays, the characterization process of highly complex transducers might involve various manual steps, which are laborious, time-consuming, and subject to errors. These factors can hinder the full characterization of a prototype transducer, leading to an under-representation or inadequate evaluation. To come to an extensive, high-quality evaluation of a prototype transducer, the acoustic characterization of each transducer element is indispensable in both transmit and receive operations. In this paper, we propose a pipeline to automatically perform the acoustic characterization of a matrix transducer using a research imaging system. The performance of the pipeline is tested on a prototype matrix transducer consisting of 960 elements. The results show that the proposed pipeline is capable of performing the complete acoustic characterization of a high-element count transducer in a fast and convenient way. @en

Objective: Described here is the development of an ultrasound matrix transducer prototype for high-frame-rate 3-D intra-cardiac echocardiography. Methods: The matrix array consists of 16 × 18 lead zirconate titanate elements with a pitch of 160 µm × 160 µm built on top of an application-specific integrated circuit that generates transmission signals and digitizes the received signals. To reduce the number of cables in the catheter to a feasible number, we implement subarray beamforming and digitization in receive and use a combination of time-division multiplexing and pulse amplitude modulation data transmission, achieving an 18-fold reduction. The proposed imaging scheme employs seven fan-shaped diverging transmit beams operating at a pulse repetition frequency of 7.7 kHz to obtain a high frame rate. The performance of the prototype is characterized, and its functionality is fully verified. Results: The transducer exhibits a transmit efficiency of 28 Pa/V at 5 cm per element and a bandwidth of 60% in transmission. In receive, a dynamic range of 80 dB is measured with a minimum detectable pressure of 10 Pa per element. The element yield of the prototype is 98%, indicating the efficacy of the manufacturing process. The transducer is capable of imaging at a frame rate of up to 1000 volumes/s and is intended to cover a volume of 70° × 70° × 10 cm. Conclusion: These advanced imaging capabilities have the potential to support complex interventional procedures and enable full-volumetric flow, tissue, and electromechanical wave tracking in the heart.@en

This paper presents an ultrasound transceiver application-specific integrated circuit (ASIC) directly integrated with an array of 12 × 80 piezoelectric transducer elements to enable next-generation ultrasound probes for 3D carotid artery imaging. The ASIC, implemented in a 0.18 µm high-voltage Bipolar-CMOS-DMOS (HV BCD) process, adopted a programmable switch matrix that allowed selected transducer elements in each row to be connected to a transmit and receive channel of an imaging system. This made the probe operate like an electronically translatable linear array, allowing large-aperture matrix arrays to be interfaced with a manageable number of system channels. This paper presents a second-generation ASIC that employed an improved switch design to minimize clock feedthrough and charge-injection effects of high-voltage metal–oxide–semiconductor field-effect transistors (HV MOSFETs), which in the first-generation ASIC caused parasitic transmis-sions and associated imaging artifacts. The proposed switch controller, implemented with cascaded non-overlapping clock generators, generated control signals with improved timing to mitigate the effects of these non-idealities. Both simulation results and electrical measurements showed a 20 dB reduction of the switching artifacts. In addition, an acoustic pulse-echo measurement successfully demonstrated a 20 dB reduction of imaging artifacts.@en

The measurement of acoustic fields generated by ultrasonic transducers is important for determining the focal length, lateral resolution, and amplitudes of the lateral and grating lobes. The acoustic field is commonly characterized by a set of scans using a needle hydrophone. The output of the hydrophone can be connected to an analog filter to enhance the signal. However, the analog filter might not be sufficient to avoid the noises that distort the signals. Alternatively, linear digital filters can be advantageous to improving the acoustic-field characterization. In this work, three filters were investigated: moving average (MA), band-pass Hamming window (HW), and band-pass Blackman window (BW). The filters were implemented and evaluated in terms of the root-mean-square error (RMSE) of the measured sound field, which was filtered, in relation to the simulated acoustic field (gold standard). As a compromise between effective filtering and signal non-distortion, a method to model the MA kernel length was proposed. All the filters reduced the noise of the measured acoustic field. The HW and the BW filters were more effective (RMSE = 4.01%) than the MA filter (RMSE = 4.28%). In spite of the small quantitative difference, acoustic field comparisons showed qualitative improvements.@en

High frame rate three-dimensional (3D) ultrasound imaging would offer excellent possibilities for the accurate assessment of carotid artery diseases. This calls for a matrix transducer with a large aperture and a vast number of elements. Such a matrix transducer should be interfaced with an application-specific integrated circuit (ASIC) for channel reduction. However, the fabrication of such a transducer integrated with one very large ASIC is very challenging and expensive. In this study, we develop a prototype matrix transducer mounted on top of multiple identical ASICs in a tiled configuration. The matrix was designed to have 7680 piezoelectric elements with a pitch of 300 μm × 150 μm integrated with an array of 8 × 1 tiled ASICs. The performance of the prototype is characterized by a series of measurements. The transducer exhibits a uniform behavior with the majority of the elements working within the −6 dB sensitivity range. In transmit, the individual elements show a center frequency of 7.5 MHz, a −6 dB bandwidth of 45%, and a transmit efficiency of 30 Pa/V at 200 mm. In receive, the dynamic range is 81 dB, and the minimum detectable pressure is 60 Pa per element. To demonstrate the imaging capabilities, we acquired 3D images using a commercial wire phantom.@en

The accurate determination of the transfer function of ultrasound transducers is important for their design and operational performance. However, conventional methods for quantifying the transfer function, such as hydrophone measurements, radiation force balance, and pulse-echo measurements, are costly and complex due to specialized equipment required. In this study, we introduce a novel approach to estimate the transfer function of ultrasound transducers by measuring the acoustic streaming velocity generated by the transducer. We utilize an experimental setup consisting of a water tank with a millimeter scale, an ink-filled syringe, and a camera for recording the streaming phenomenon. Through streaming velocity measurements in the frequency range from 2 to 8 MHz, we determined the transfer function of an unfocused circular transducer with a center frequency of 5 MHz and a radius of 5.6 mm. We compared the performance of our method with hydrophone and pulse-echo measurements. At the center frequency, we measured a transmit efficiency of 1.9 kPa/V using the streaming approach, while hydrophone and pulse-echo measurements yielded transmit efficiencies of 2.1 kPa/V and 1.8 kPa/V, respectively. These findings demonstrate that the proposed method for estimating the transfer function of ultrasound transducers achieves a sufficient level of accuracy comparable to pulse-echo and hydrophone measurements.@en

Cardiovascular diseases stand as the leading cause of death worldwide. Cardiovascular diseases are a group of disorders of the heart and blood vessels, such as atherosclerosis, congenital heart diseases, rheumatic heart diseases, and arrhythmias. Early detection of cardiovascular issues is imperative for effective treatment, and the implementation of screening programs facilitates timely identification and intervention, ultimately reducing morbidity rates. Ultrasound imaging is a widely utilized technique for assessing cardiovascular diseases due to its portability, lack of radiation exposure, and relatively lower associated costs compared to other imaging modalities such as magnetic resonance imaging and computed tomography. In this thesis, we detail the development of specialized ultrasound probes for three distinct cardiovascular applications: carotid artery imaging, intracardiac echocardiography, and abdominal aorta imaging. These applications necessitate high-frame-rate 3D imaging with a wide field of view, requiring ultrasound matrix transducers with a vast number of elements and integrated electronics. We outline the design, fabrication, and characterization of three probes tailored for each specific application. The thesis is divided into two parts. The first part focuses on simplifying and automating the acoustic characterization process of ultrasound transducers. The second part explores the design, manufacturing, characterization, and imaging of dedicated matrix transducers featuring integrated Application-Specific Integrated Circuits (ASICs). @en

Purpose This paper investigates the use of shear wave elastography (SWE) in deep tissues with a two-dimensional (2D) transducer array. Methods A 130-element 800-kHz 2D array for SWE in regions deeper than 100 mm is designed, fabricated, and characterized. SWE simulations are performed with the proposed 2D array in a tissue-like medium. Results The pressure field of the proposed transducer was recorded and utilized to simulate the generation of acoustic radiation force in deep tissues. The elasticity map of the tissue was successfully reconstructed by tracking the speed of shear wave propagation at 120 mm depth. Conclusion This study suggests that a 2D transducer with proper parameters may provide a means for extending the depth range of SWE.@en

Purpose This paper investigates the use of shear wave elastography (SWE) in deep tissues with a two-dimensional (2D) transducer array. Methods A 130-element 800-kHz 2D array for SWE in regions deeper than 100 mm is designed, fabricated, and characterized. SWE simulations are performed with the proposed 2D array in a tissue-like medium. Results The pressure field of the proposed transducer was recorded and utilized to simulate the generation of acoustic radiation force in deep tissues. The elasticity map of the tissue was successfully reconstructed by tracking the speed of shear wave propagation at 120 mm depth. Conclusion This study suggests that a 2D transducer with proper parameters may provide a means for extending the depth range of SWE.@en